Saturday, April 5, 2025 4/5/2025

Characterization and treatment of the scarred vocal fold

Award Number: R01DC004428
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Characterization and treatment of the scarred vocal fold - Project Summary/Abstract Vocal fold (VF) mucosal injury resulting in scar formation is a debilitating and challenging clinical problem for which there is no uniformly effective treatment. Emerging research, including work completed during our most recent funding cycle, suggests that non-resident, migratory cells may play an important and previously underappreciated role in VF wound healing and tissue remodeling. The migratory cells of particular importance to VF mucosal maintenance and repair are those within the monocyte lineage, a diverse population that arises from myeloid progenitor cells within bone marrow. Based on the scientific premise that bone marrow-derived, monocyte-lineage cells are key effectors of wound healing outcome, we propose a definitive set of experiments that will quantify bone marrow-derived cell migration to normal and injured VF mucosa (Aim 1), identify the functional contribution of monocyte-lineage cells to inflammatory signaling and fibrosis outcome following VF mucosal injury (Aim 2), and determine phonatory outcomes following monocyte-lineage cell neutralization in a humanized rat model of VF mucosal injury (Aim 3). The proposed research will define the relationship between monocyte-lineage cell availability and VF wound healing outcome and, further, provide a foundation for future work in the area of VF scar prophylaxis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $530,299 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	18	3/11/2025	NON-COMPETING CONTINUATION	$530,299
														Subtotal = $530,299

Issue Date FY: 2024 ( Subtotal = $515,956 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	17	3/26/2024	NON-COMPETING CONTINUATION	$515,956
														Subtotal = $515,956

Issue Date FY: 2023 ( Subtotal = $515,956 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	16	3/15/2023	COMPETING CONTINUATION	$515,956
														Subtotal = $515,956

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	15	5/21/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	15	1/15/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $531,182 )
2016	2016	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	15	1/11/2016	EXTENSION WITH OR WITHOUT FUNDS	$531,182
														Subtotal = $531,182

Issue Date FY: 2015 ( Subtotal = $525,870 )
2015	2015	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	14	1/21/2015	NON-COMPETING CONTINUATION	$525,870
														Subtotal = $525,870

Issue Date FY: 2014 ( Subtotal = $563,292 )
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	12	11/11/2013	SUPPLEMENT FOR EXPANSION	$29,551
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	001	13	1/24/2014	NON-COMPETING CONTINUATION	$480,366
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	002	13	2/6/2014	NON-COMPETING CONTINUATION	$53,375
														Subtotal = $563,292

Issue Date FY: 2013 ( Subtotal = $531,885 )
2013	2013	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	12	1/17/2013	NON-COMPETING CONTINUATION	$531,885
														Subtotal = $531,885

Issue Date FY: 2012 ( Subtotal = $599,941 )
2012	2012	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	11	3/29/2012	COMPETING CONTINUATION	$599,941
														Subtotal = $599,941

Issue Date FY: 2010 ( Subtotal = $480,529 )
2010	2010	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	10	6/9/2010	NON-COMPETING CONTINUATION	$480,529
														Subtotal = $480,529

Issue Date FY: 2009 ( Subtotal = $725,781 )
2009	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Trans-NIH Recovery Act Research Support	002	9	8/12/2009	SUPPLEMENT FOR EXPANSION	$177,086
2009	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	8	3/26/2009	SUPPLEMENT FOR EXPANSION	$37,125
2009	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	001	9	6/19/2009	NON-COMPETING CONTINUATION	$511,570
														Subtotal = $725,781

Issue Date FY: 2008 ( Subtotal = $352,497 )
2008	2008	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	8	6/20/2008	NON-COMPETING CONTINUATION	$352,497
														Subtotal = $352,497

Issue Date FY: 2007 ( Subtotal = $346,737 )
2007	2007	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	7	6/22/2007	NON-COMPETING CONTINUATION	$346,737
														Subtotal = $346,737

Issue Date FY: 2006 ( Subtotal = $360,761 )
2006	2006	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	6	6/30/2006	COMPETING CONTINUATION	$360,761
														Subtotal = $360,761

Issue Date FY: 2004 ( Subtotal = $292,077 )
2004	2004	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	5	5/1/2004	NON-COMPETING CONTINUATION	$292,077
														Subtotal = $292,077

Issue Date FY: 2003 ( Subtotal = $292,077 )
2003	2003	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	4		NON-COMPETING CONTINUATION	$292,077
														Subtotal = $292,077

Issue Date FY: 2002 ( Subtotal = $310,265 )
2002	2002	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	3	5/6/2002	NON-COMPETING CONTINUATION	$310,265
														Subtotal = $310,265

Issue Date FY: 2001 ( Subtotal = $327,304 )
2001	2001	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	2	4/30/2001	NON-COMPETING CONTINUATION	$318,692
2001	2001	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	001	1	1/8/2001	SUPPLEMENT FOR EXPANSION	$8,612
														Subtotal = $327,304

Issue Date FY: 2000 ( Subtotal = $302,416 )
2000	2000	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	1	4/26/2000	NEW	$302,416
														Subtotal = $302,416

Grand Total All Awards = $8,104,825

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Characterization and treatment of the scarred vocal fold

Award Number: R01DC004428

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer