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HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS

Award Number: R01DC004412
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2001
PERIOD OF PERFORMANCE END DATE: 12/31/2005

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HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS - DESCRIPTION: The present application will study development of ascending projections that terminate within the inferior colliculus in non-overlapping or only partially overlapping patterns of bands and patches. Bands of afferent termination represent a vertical segregation across the thickness of the fibrodendritic layers of the inferior colliculus and patches represent a horizontal segregation along the plane of the layers. It is not known whether these patterns are established as the afferent fibers first enter the inferior colliculus or whether they form secondarily from an initial overlap. Nevertheless these afferent patterns, together with the parallel fibrodendritic architecture of the inferior colliculus, determine the synaptic interactions that take place within the nucleus. In order to understand how neural circuits involved in information processing develop, the proposed studies will identify 1) the spatial and temporal characteristics of arrival, distribution and refinement of afferent projections, 2) the relationship of those events to synaptogenesis and 3) the mechanisms that govern the formation of the pattern of afferent termination within the layers. Specifically, experiments will address these issues by studying the development of the ascending projections to the inferior colliculus from the lateral superior olive (LSO) and dorsal nucleus of the lateral lemniscus (DNLL) in an altricial mammal, the ferret. The position and distribution of the LSO and DNLL axons projecting to the inferior colliculus will be studied in a normal developmental series of ferret kits and an experimental series with cochlear ablations. Lipophilic carbocyanine dyes, DiI and DiD, will be used to label the ipsilateral and contralateral LSO and the commissure of DNLL fibers. In addition, the distribution of synaptic contacts along the tonotopic axis and parallel to the fibrodendritic layers will be sampled at developmental time points determined from the tracing studies. Knowledge of the development of afferent projections to the inferior colliculus, and the integrative circuits that ultimately result, is critical in understanding auditory functions that may be at risk due to genetic anomaly, nutritional imbalance, effects of teratogens during pregnancy or perhaps even to premature birth. While subsequent auditory experience may alter intrinsic auditory circuits, the initial construction of functional circuits remains fundamental to understanding neural and behavioral plasticity that may lead to rational intervention and treatment outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $294,840 )
2005	2005	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Research Related to Deafness and Communication Disorders	000	5	12/10/2004	NON-COMPETING CONTINUATION	$294,840
														Subtotal = $294,840

Issue Date FY: 2004 ( Subtotal = $294,840 )
2004	2004	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Research Related to Deafness and Communication Disorders	000	4	12/22/2003	NON-COMPETING CONTINUATION	$294,840
														Subtotal = $294,840

Issue Date FY: 2003 ( Subtotal = $294,840 )
2003	2003	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Research Related to Deafness and Communication Disorders	000	3		NON-COMPETING CONTINUATION	$294,840
														Subtotal = $294,840

Issue Date FY: 2002 ( Subtotal = $262,535 )
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Research Related to Deafness and Communication Disorders	000	2	1/15/2002	NON-COMPETING CONTINUATION	$262,535
														Subtotal = $262,535

Issue Date FY: 2001 ( Subtotal = $310,778 )
2001	2001	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Research Related to Deafness and Communication Disorders	000	1	1/14/2001	NEW	$310,778
														Subtotal = $310,778

Grand Total All Awards = $1,457,833

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HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS

Award Number: R01DC004412

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2001

PERIOD OF PERFORMANCE END DATE: 12/31/2005

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