Thursday, December 26, 2024 12/26/2024

Human Auditory Cortex Physiology

Award Number: R01DC004290
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Speech sounds are the most important sounds that humans hear, yet our knowledge of how the complex cortical network of auditory and auditory-related brain regions subserves speech perception is limited. Our overarching goal is to understand where and how speech information is represented within this network. The focus of this proposal is to test directly predictive coding models of speech perception. In predictive coding hypotheses, the brain minimizes the differences between internally generated expectations and sensory observations through an ongoing interaction between sensory and higher-order cortical regions. We use novel combinations of complementary invasive and non-invasive experimental methods to study these brain regions in neurosurgery patients who require placement of chronic intracranial electrodes. These experiments involve combining direct cortical electrophysiological recording methods with non-invasive electroencephalography, electrical stimulation techniques and anatomical and functional neuroimaging methods. We also obtain causal evidence of network functional properties by studying the effects of selectively disrupting the function of specific components of this network. Our investigative strategy makes use of these unique experimental opportunities to overcome long-standing barriers to progress in this research field. We will pursue our goals by testing hypotheses regarding: (1) the locations, functional properties and connectivity patterns of auditory cortical fields and auditory-related cortices of the temporal and frontal lobes that are engaged in speech processing, (2) predictive coding models of speech signaling within this network, and (3) the behavioral consequences and neural signatures of selective disruption of the network. These objectives are pursued by an experienced multidisciplinary group of investigators with expertise encompassing all required clinical and research topic areas. To our knowledge, the resulting data will be the first of its kind to directly demonstrate how speech information is processed at all levels of auditory cortical hierarchy and provide causal evidence of the role of feedback projections on speech information processing within canonical auditory cortex. Detailed characterization of this network will improve our understanding of the pathophysiology of disease states affecting this system and will provide mechanistic insights that are required to inform the design of new treatment strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $549,747 )
2025	2025	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	25	11/29/2024	NON-COMPETING CONTINUATION	$549,747
														Subtotal = $549,747

Issue Date FY: 2024 ( Subtotal = $615,817 )
2024	2024	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	24	5/2/2024	NON-COMPETING CONTINUATION	$61,582
2024	2024	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	24	12/29/2023	NON-COMPETING CONTINUATION	$554,235
														Subtotal = $615,817

Issue Date FY: 2023 ( Subtotal = $622,291 )
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	23	2/16/2023	NON-COMPETING CONTINUATION	$622,291
														Subtotal = $622,291

Issue Date FY: 2022 ( Subtotal = $630,661 )
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	22	11/22/2021	NON-COMPETING CONTINUATION	$567,597
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	22	4/18/2022	NON-COMPETING CONTINUATION	$63,064
														Subtotal = $630,661

Issue Date FY: 2021 ( Subtotal = $685,285 )
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	21	11/27/2020	COMPETING CONTINUATION	$685,285
2021	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	20	6/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $685,285

Issue Date FY: 2020 ( Subtotal = $610,914 )
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	20	11/21/2019	NON-COMPETING CONTINUATION	$549,823
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	20	1/16/2020	NON-COMPETING CONTINUATION	$61,091
														Subtotal = $610,914

Issue Date FY: 2019 ( Subtotal = $618,071 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	19	11/15/2018	NON-COMPETING CONTINUATION	$618,071
														Subtotal = $618,071

Issue Date FY: 2018 ( Subtotal = $617,912 )
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	18	4/4/2018	NON-COMPETING CONTINUATION	$61,789
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	18	11/24/2017	NON-COMPETING CONTINUATION	$556,123
														Subtotal = $617,912

Issue Date FY: 2017 ( Subtotal = $614,006 )
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	17	5/24/2017	NON-COMPETING CONTINUATION	$61,399
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	17	11/23/2016	NON-COMPETING CONTINUATION	$552,607
														Subtotal = $614,006

Issue Date FY: 2016 ( Subtotal = $666,827 )
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	16	11/4/2015	COMPETING CONTINUATION	$664,514
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	16	2/16/2016	COMPETING CONTINUATION	$2,313
														Subtotal = $666,827

Issue Date FY: 2015 ( Subtotal = $568,311 )
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	15	1/13/2015	NON-COMPETING CONTINUATION	$51,664
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	15	11/6/2014	NON-COMPETING CONTINUATION	$516,647
														Subtotal = $568,311

Issue Date FY: 2014 ( Subtotal = $574,051 )
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	14	2/10/2014	NON-COMPETING CONTINUATION	$57,405
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	14	11/13/2013	NON-COMPETING CONTINUATION	$516,646
														Subtotal = $574,051

Issue Date FY: 2013 ( Subtotal = $545,350 )
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	13	10/25/2012	NON-COMPETING CONTINUATION	$523,679
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	13	5/10/2013	NON-COMPETING CONTINUATION	$21,671
														Subtotal = $545,350

Issue Date FY: 2012 ( Subtotal = $574,051 )
2012	2012	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	12	11/15/2011	NON-COMPETING CONTINUATION	$532,146
2012	2012	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	12	1/27/2012	NON-COMPETING CONTINUATION	$41,905
														Subtotal = $574,051

Issue Date FY: 2011 ( Subtotal = $597,803 )
2011	2011	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	11	11/4/2010	COMPETING CONTINUATION	$598,959
2011	2011	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	11	11/17/2010	COMPETING CONTINUATION	-$1,156
														Subtotal = $597,803

Issue Date FY: 2010 ( Subtotal = $556,967 )
2010	2010	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	10	11/6/2009	NON-COMPETING CONTINUATION	$506,334
2010	2010	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	10	1/21/2010	NON-COMPETING CONTINUATION	$50,633
														Subtotal = $556,967

Issue Date FY: 2009 ( Subtotal = $550,581 )
2009	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	9	11/20/2008	NON-COMPETING CONTINUATION	$495,522
2009	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	9	3/16/2009	NON-COMPETING CONTINUATION	$55,059
														Subtotal = $550,581

Issue Date FY: 2008 ( Subtotal = $538,900 )
2008	2008	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	8	11/21/2007	NON-COMPETING CONTINUATION	$538,900
														Subtotal = $538,900

Grand Total All Awards = $13,679,747

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Human Auditory Cortex Physiology

Award Number: R01DC004290

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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