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Development of Neuronal Circuits In The Auditory Systems

Award Number: R01DC004199
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1999
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Development of Neuronal Circuits In The Auditory Systems - Project Summary Accurate and efficient auditory perception relies on precisely organized and functionally specialized neuronal connections and synaptic circuits. The long-term goal of this research program is to elucidate the synaptic and cellular mechanisms whereby auditory circuits in the developing brain achieve their precise functional and structural organization. We investigate these mechanisms in the sound localization pathway from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO). The MNTB-LSO pathway is a well- characterized, inhibitory, glycinergic pathway with a precise tonotopic organization. During development, the MNTB-LSO pathway undergoes a remarkable degree of reorganization, which significantly increases the precision of its tonotopic organization. This refinement occurs to a large degree before hearing onset and during the past funding period we have provided evidence that the precise temporal pattern of spontaneous activity before hearing onset plays a crucial role in this reorganization. This proposal seeks to investigate the synaptic mechanism whereby patterned activity exerts its effect on developing MNTB-LSO synapses to regulate tonotopic refinement. To approach this we will 1) characterized the mechanism underlying activity- dependent, patterned-sensitive long-term potentiation at inhibitory MNTB-LSO synapses before hearing onset, 2) elucidate the developmental role of GABA co-release from developing glycinergic MNTB-LSO synapses, and 3) characterize the effects of activity-dependent zinc release from developing MNTB-LSO synapses on synaptic transmission and reveal its role in circuit reorganization. To achieve these goals we will apply a broad repertoire of electrophysiological, imaging, and anatomical techniques to brain slices obtained from normal and genetically modified mice. Results from the proposed experiments will provide novel insight into basic mechanisms governing the formation of precisely organized auditory brain circuits. Information about these mechanisms is important to understand the biological causes that underlie developmental auditory processing deficits in humans, including central auditory processing disorder and developmental dyslexia, which are associated with abnormal auditory processing on the brainstem level.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$871 )
2022	2020	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	22	12/7/2021	NON-COMPETING CONTINUATION	-$72
2022	2020	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	003	22	7/13/2022	NON-COMPETING CONTINUATION	-$799
2022	2009	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Trans-NIH Recovery Act Research Support	002	11	1/11/2022	SUPPLEMENT FOR EXPANSION	-$72
2022	2009	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Trans-NIH Recovery Act Research Support	000	11	12/7/2021	SUPPLEMENT FOR EXPANSION	$72
														Subtotal = -$871

Issue Date FY: 2020 ( Subtotal = $531,107 )
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	22	6/5/2020	NON-COMPETING CONTINUATION	$531,107
														Subtotal = $531,107

Issue Date FY: 2019 ( Subtotal = $531,107 )
2019	2019	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	21	6/5/2019	NON-COMPETING CONTINUATION	$531,107
														Subtotal = $531,107

Issue Date FY: 2018 ( Subtotal = $531,107 )
2018	2018	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	20	6/8/2018	NON-COMPETING CONTINUATION	$531,107
														Subtotal = $531,107

Issue Date FY: 2017 ( Subtotal = $527,713 )
2017	2017	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	19	6/13/2017	NON-COMPETING CONTINUATION	$527,713
2017	2016	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	18	12/5/2016	COMPETING CONTINUATION	$42,509
2017	2015	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	17	11/30/2016	NON-COMPETING CONTINUATION	-$42,509
														Subtotal = $527,713

Issue Date FY: 2016 ( Subtotal = $522,623 )
2016	2016	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	18	5/27/2016	COMPETING CONTINUATION	$522,623
														Subtotal = $522,623

Issue Date FY: 2015 ( Subtotal = $532,592 )
2015	2015	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	17	6/10/2015	NON-COMPETING CONTINUATION	$532,592
														Subtotal = $532,592

Issue Date FY: 2014 ( Subtotal = $537,973 )
2014	2014	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	16	6/3/2014	NON-COMPETING CONTINUATION	$537,973
														Subtotal = $537,973

Issue Date FY: 2013 ( Subtotal = $511,074 )
2013	2013	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	15	6/6/2013	NON-COMPETING CONTINUATION	$511,074
														Subtotal = $511,074

Issue Date FY: 2012 ( Subtotal = $537,973 )
2012	2012	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	14	5/10/2012	NON-COMPETING CONTINUATION	$537,973
														Subtotal = $537,973

Issue Date FY: 2011 ( Subtotal = $550,848 )
2011	2011	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	13	6/15/2011	COMPETING CONTINUATION	$550,848
2011	2010	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	12	6/15/2011	NON-COMPETING CONTINUATION	$0
2011	2009	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Trans-NIH Recovery Act Research Support	000	11	4/7/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $550,848

Issue Date FY: 2010 ( Subtotal = $401,541 )
2010	2010	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	12	1/20/2010	NON-COMPETING CONTINUATION	$36,504
2010	2010	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	12	11/12/2009	NON-COMPETING CONTINUATION	$365,037
														Subtotal = $401,541

Issue Date FY: 2009 ( Subtotal = $677,493 )
2009	2009	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Trans-NIH Recovery Act Research Support	002	11	7/10/2009	SUPPLEMENT FOR EXPANSION	$231,694
2009	2009	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	11	3/16/2009	NON-COMPETING CONTINUATION	$44,325
2009	2009	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Trans-NIH Recovery Act Research Support	003	11	8/4/2009	SUPPLEMENT FOR EXPANSION	$2,546
2009	2009	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	11	11/14/2008	NON-COMPETING CONTINUATION	$398,928
														Subtotal = $677,493

Issue Date FY: 2008 ( Subtotal = $331,296 )
2008	2008	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	10	11/20/2007	NON-COMPETING CONTINUATION	$293,904
2008	2008	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	10	9/8/2008	SUPPLEMENT FOR EXPANSION	$37,392
														Subtotal = $331,296

Issue Date FY: 2007 ( Subtotal = $298,026 )
2007	2007	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	9	11/14/2006	NON-COMPETING CONTINUATION	$298,026
														Subtotal = $298,026

Issue Date FY: 2006 ( Subtotal = $306,838 )
2006	2006	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	8	1/6/2006	SUPPLEMENT FOR EXPANSION	$11,408
2006	2006	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	8	12/1/2005	COMPETING CONTINUATION	$295,430
														Subtotal = $306,838

Issue Date FY: 2005 ( Subtotal = $54,439 )
2005	2005	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	7	7/12/2005	NON-COMPETING CONTINUATION	$54,439
														Subtotal = $54,439

Issue Date FY: 2004 ( Subtotal = $211,416 )
2004	2004	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	6	7/16/2004	NON-COMPETING CONTINUATION	$211,416
														Subtotal = $211,416

Issue Date FY: 2003 ( Subtotal = $254,938 ) (Continued on the next page)
Grand Total All Awards = $8,696,038

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Development of Neuronal Circuits In The Auditory Systems

Award Number: R01DC004199

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1999

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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