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Active and Nonlinear Models for Cochlear Mechanics

Award Number: R01DC004084
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY: Rotation of the hair bundles (HB) of the inner hair cells (IHC) of the cochlea open the mechano-electric transducer (MET) channels of the IHCs. The resulting current depolarizes the cell body inducing neurotransmitter release and, ultimately, auditory nerve stimulation. The active machinery of the cochlea, driven by motility of outer hair cells (OHC), both tunes the excitation of the IHC HBs and provides for nonlinear compression. The first specific aim of the grant involves the quantification of cochlear vibrations when no sound is presented, to characterize noise floor and test the theory of the cochlear amplifier. The second aim is to predict the cochlear response to simple and complex acoustic signals and to determine the effect of attachment of IHC mechanically to the tectorial membrane. Particular emphasis is placed on testing rate-dependent effects in MET models (including adaptation) and in OHC electromechanics. The specific aims of this grant are to develop mathematical models of these phenomenon, to rigorously test these hypotheses via comparison to existing experiments, and to work with our collaborators to devise feasible new experiments to test our predictions. The overarching goal of this research is to develop a complete fluid-mechanical-electrical model that describes the response of the cochlea to both external acoustic stimulation. If successful, this model will enhance our understanding of failure mechanisms in the cochlea, answering important questions as to the morphological elements of the cochlea that fail and why. Such understanding will improve noninvasive diagnosis of hearing as abnormalities in the response can be linked to specific pathologies. Finally, having an understanding of how the cochlea process sound over the entire spectrum will help us to understand how important classes of signals are processed in the cochlea (such as speech and music) and such understanding can lead to better speech processing algorithms or cochlear implant electrical stimulation approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	21	10/10/2024	COMPETING CONTINUATION	$11,109
2025	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	20	10/10/2024	NON-COMPETING CONTINUATION	-$11,109
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $552,002 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	21	3/21/2024	COMPETING CONTINUATION	$552,002
														Subtotal = $552,002

Issue Date FY: 2022 ( Subtotal = $311,973 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	20	4/21/2022	NON-COMPETING CONTINUATION	$31,198
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	20	2/11/2022	NON-COMPETING CONTINUATION	$280,775
														Subtotal = $311,973

Issue Date FY: 2021 ( Subtotal = $538,287 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	19	2/9/2021	NON-COMPETING CONTINUATION	$313,079
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	19	8/12/2021	SUPPLEMENT FOR EXPANSION	$225,208
														Subtotal = $538,287

Issue Date FY: 2020 ( Subtotal = $303,934 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	18	1/29/2020	NON-COMPETING CONTINUATION	$303,934
														Subtotal = $303,934

Issue Date FY: 2019 ( Subtotal = $305,493 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	17	2/22/2019	NON-COMPETING CONTINUATION	$305,493
														Subtotal = $305,493

Issue Date FY: 2018 ( Subtotal = $306,405 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	003	16	7/23/2018	COMPETING CONTINUATION	$3,178
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	16	3/1/2018	COMPETING CONTINUATION	$306,405
2018	2016	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	002	15	7/23/2018	EXTENSION WITH OR WITHOUT FUNDS	-$3,178
2018	2016	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	15	3/1/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $306,405

Issue Date FY: 2016 ( Subtotal = $249,847 )
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	15	5/5/2016	EXTENSION WITH OR WITHOUT FUNDS	$249,847
														Subtotal = $249,847

Issue Date FY: 2015 ( Subtotal = $248,161 )
2015	2015	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	14	5/12/2015	NON-COMPETING CONTINUATION	$248,161
														Subtotal = $248,161

Issue Date FY: 2014 ( Subtotal = $242,465 )
2014	2014	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	13	4/15/2014	NON-COMPETING CONTINUATION	$242,465
														Subtotal = $242,465

Issue Date FY: 2013 ( Subtotal = $231,518 )
2013	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	12	5/17/2013	NON-COMPETING CONTINUATION	$231,518
														Subtotal = $231,518

Issue Date FY: 2012 ( Subtotal = $238,898 )
2012	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	11	6/14/2012	COMPETING CONTINUATION	$238,898
														Subtotal = $238,898

Issue Date FY: 2010 ( Subtotal = $207,711 )
2010	2010	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	10	2/5/2010	NON-COMPETING CONTINUATION	$207,711
														Subtotal = $207,711

Issue Date FY: 2009 ( Subtotal = $210,010 )
2009	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	9	3/18/2009	NON-COMPETING CONTINUATION	$21,001
2009	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	9	2/3/2009	NON-COMPETING CONTINUATION	$189,009
														Subtotal = $210,010

Issue Date FY: 2008 ( Subtotal = $210,204 )
2008	2008	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	8	2/19/2008	NON-COMPETING CONTINUATION	$210,204
														Subtotal = $210,204

Issue Date FY: 2007 ( Subtotal = $213,164 )
2007	2007	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	7	2/28/2007	NON-COMPETING CONTINUATION	$213,164
														Subtotal = $213,164

Issue Date FY: 2006 ( Subtotal = $220,177 )
2006	2006	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	6	1/27/2006	COMPETING CONTINUATION	$220,177
														Subtotal = $220,177

Issue Date FY: 2003 ( Subtotal = $181,856 )
2003	2003	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	5		NON-COMPETING CONTINUATION	$181,856
														Subtotal = $181,856

Issue Date FY: 2002 ( Subtotal = $176,559 )
2002	2002	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	4	4/26/2002	NON-COMPETING CONTINUATION	$176,559
														Subtotal = $176,559

Issue Date FY: 2001 ( Subtotal = $171,417 )
2001	2001	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	3	4/27/2001	NON-COMPETING CONTINUATION	$171,417
														Subtotal = $171,417

Issue Date FY: 2000 ( Subtotal = $166,424 )
2000	2000	Regents of the University of Michigan	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	2	4/20/2000	NON-COMPETING CONTINUATION	$166,424
														Subtotal = $166,424

Issue Date FY: 1999 ( Subtotal = $179,578 ) (Continued on the next page)
Grand Total All Awards = $5,466,083

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Active and Nonlinear Models for Cochlear Mechanics

Award Number: R01DC004084

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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