Monday, February 16, 2026 2/16/2026

Cortical processing of olfactory stimuli

Award Number: R01DC003906
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1998
PERIOD OF PERFORMANCE END DATE: 11/30/2012

Group Awards By:

View Award Description

Cortical processing of olfactory stimuli - DESCRIPTION (provided by applicant): Cortical processing of sensory information plays a critical role in sensory discrimination, object recognition and memory. Cortical sensory processing has been shown to be highly dynamic, with past experience, current context and expectations shaping how the world is perceived on a moment by moment basis. Disorders of sensory processing constitute a major component of impairments induced by CNS disease and aging, as well as congenital disorders such as schizophrenia and autism. A largely overlooked aspect of odor processing is the role of top-down inputs in shaping olfactory cortical activity based on past-experience, expectation and context. Here we propose to explore the role of the lateral entorhinal cortex (LEC) in both odor processing and top-down control of piriform cortex (PCX ) and olfactory bulb. The LEC is both a component of the olfactory cortex (receives direct input from the olfactory bulb) and is a major component of the temporal lobe/limbic system memory circuitry as the primary afferent to the hippocampal formation. Importantly, the LEC also sends a strong projection back to the PCX and olfactory bulb - a pathway not well understood. There are three specific aims, each supported by new preliminary data, that test novel, specific hypotheses about the function of LEC in olfaction. In Specific Aim 1 we will extend our initial work showing significantly more selective single-unit odor receptive fields in LEC compared to PCX. First we will use in vivo intracellular recording in anesthetized animals to allow odor RF characterization of identified LEC cell types, and second we will compare single-unit and ensemble odor evoked activity in the awake, freely moving LEC and PCX to novel and familiar odors. These data will be the first to characterize olfactory sensory physiology of this region of olfactory cortex, and test our hypothesis that odor coding becomes more precise, in an experience-dependent manner, in this neocortical component of the olfactory cortex. In Aim 2, using optogenetic and reversible lesion techniques we will extend our preliminary data to test the hypothesis that LEC feedback to PCX functions in a highly cell specific manner to shape both PCX neuron odor RF's and temporal structure of PCX activity. This top-down influence may contribute to both perceptual acuity and odor memory as tested in Aim 3. In Aim 3 we will extend our preliminary data in awake, freely moving animals performing odor discrimination tasks to test our hypothesis that LEC top-down input shapes odor acuity both by modulating ongoing PCX odor-evoked activity and by contributing to anticipatory PCX single-unit and ensemble activity, prior to odor onset. Each Aim uses innovative concepts and techniques to test specific hypotheses regarding the role of a structure that serves not only as a component of the olfactory cortex, but also as a critical component of temporal lobe memory circuits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$129,311 )
2020	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	20	9/10/2020	NON-COMPETING CONTINUATION	-$129,311
														Subtotal = -$129,311

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	20	1/23/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $324,536 )
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	20	5/24/2017	NON-COMPETING CONTINUATION	$32,455
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	20	2/10/2017	NON-COMPETING CONTINUATION	$292,081
														Subtotal = $324,536

Issue Date FY: 2016 ( Subtotal = $324,563 )
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	19	2/24/2016	EXTENSION WITH OR WITHOUT FUNDS	$324,563
														Subtotal = $324,563

Issue Date FY: 2015 ( Subtotal = $321,342 )
2015	2015	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	18	2/24/2015	NON-COMPETING CONTINUATION	$321,342
														Subtotal = $321,342

Issue Date FY: 2014 ( Subtotal = $324,588 )
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	17	2/10/2014	NON-COMPETING CONTINUATION	$324,588
														Subtotal = $324,588

Issue Date FY: 2013 ( Subtotal = $341,963 )
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	16	3/7/2013	COMPETING CONTINUATION	$341,963
2013	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	15	3/6/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $341,963

Issue Date FY: 2012 ( Subtotal = $281,604 )
2012	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	15	1/26/2012	NON-COMPETING CONTINUATION	$28,151
2012	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	15	11/3/2011	NON-COMPETING CONTINUATION	$253,453
														Subtotal = $281,604

Issue Date FY: 2011 ( Subtotal = $279,333 )
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	14	6/1/2011	NON-COMPETING CONTINUATION	$19,622
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	14	11/10/2010	NON-COMPETING CONTINUATION	$259,711
														Subtotal = $279,333

Issue Date FY: 2010 ( Subtotal = $286,291 )
2010	2010	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	13	1/18/2010	NON-COMPETING CONTINUATION	$26,026
2010	2010	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	13	11/6/2009	NON-COMPETING CONTINUATION	$260,265
														Subtotal = $286,291

Issue Date FY: 2009 ( Subtotal = $264,570 )
2009	2009	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	003	12	3/16/2009	NON-COMPETING CONTINUATION	$28,694
2009	2009	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	12	2/6/2009	NON-COMPETING CONTINUATION	$258,254
2009	2008	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	10	11/14/2008	COMPETING CONTINUATION	-$231,661
2009	2008	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	11	11/14/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$209,283
														Subtotal = $264,570

Issue Date FY: 2008 ( Subtotal = $305,948 )
2008	2008	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	10	12/3/2007	COMPETING CONTINUATION	$305,948
														Subtotal = $305,948

Issue Date FY: 2007 ( Subtotal = $156,930 )
2007	2007	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	9	11/7/2006	NON-COMPETING CONTINUATION	$156,930
														Subtotal = $156,930

Issue Date FY: 2006 ( Subtotal = $161,617 )
2006	2006	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	8	11/24/2005	NON-COMPETING CONTINUATION	$161,617
														Subtotal = $161,617

Issue Date FY: 2005 ( Subtotal = $165,506 )
2005	2005	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	7	12/6/2004	NON-COMPETING CONTINUATION	$165,506
														Subtotal = $165,506

Issue Date FY: 2004 ( Subtotal = $165,506 )
2004	2004	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	555 CONSTITUTION ST., STE. 237	NORMAN	OK	73072	CLEVELAND	USA	Research Related to Deafness and Communication Disorders	000	6	12/15/2003	NON-COMPETING CONTINUATION	$165,506
														Subtotal = $165,506

Issue Date FY: 2003 ( Subtotal = $190,327 )
2003	2003	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	555 CONSTITUTION ST., STE. 237	NORMAN	OK	73072	CLEVELAND	USA	Research Related to Deafness and Communication Disorders	000	5		COMPETING CONTINUATION	$190,327
														Subtotal = $190,327

Issue Date FY: 2002 ( Subtotal = $108,495 )
2002	2002	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	555 CONSTITUTION ST., STE. 237	NORMAN	OK	73072	CLEVELAND	USA	Research Related to Deafness and Communication Disorders	000	4	11/19/2001	NON-COMPETING CONTINUATION	$108,495
														Subtotal = $108,495

Issue Date FY: 2001 ( Subtotal = $107,834 )
2001	2001	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	555 CONSTITUTION ST., STE. 237	NORMAN	OK	73072	CLEVELAND	USA	Research Related to Deafness and Communication Disorders	000	3	2/8/2001	NON-COMPETING CONTINUATION	$107,834
														Subtotal = $107,834

Issue Date FY: 2000 ( Subtotal = $102,266 )
2000	2000	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	2	11/4/1999	NON-COMPETING CONTINUATION	$102,266
														Subtotal = $102,266

Issue Date FY: 1999 ( Subtotal = $101,828 )
1999	1999	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Research Related to Deafness and Communication Disorders	000	1	11/20/1998	NEW	$101,828
														Subtotal = $101,828

Grand Total All Awards = $4,185,736

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Cortical processing of olfactory stimuli

Award Number: R01DC003906

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1998

PERIOD OF PERFORMANCE END DATE: 11/30/2012

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer