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ACOUSTIC RESPONSES OF THE HUMAN COCHLEA AND MIDDLE EAR

Award Number: R01DC003784
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/1999
PERIOD OF PERFORMANCE END DATE: 02/28/2009

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ACOUSTIC RESPONSES OF THE HUMAN COCHLEA AND MIDDLE EAR - DESCRIPTION (provided by applicant): The primary goal of this application is to use a combination of acoustic and behavioral responses to test theories of auditory processing at the mechanical and behavioral levels. A subordinate goal is to relate acoustic responses measured non-invasively in the ear canal to cochlear and middle ear function. The first aim studies the relationships between middle ear and cochlear mechanics using a combination of experimental and theoretical approaches. Measurements of stimulus-frequency otoacoustic emission (SFOAE) and otoreflectance measurements will be used to predict hearing loss, an improved test of acoustic reflex function will be used to study middle-ear noise sources and no linearity, and time-domain models of middle-ear and cochlear energy transmission will be developed and evaluated based on experimental measurements performed in this application or reported in the literature. The second aim studies the effects of cochlear no linearity on spectral processing using SFOAE stimulus conditions similar to those used in behavioral experiments on simultaneous and non-simultaneous masking and suppression. Specifically, the experiments will address the extent to which SFOAE measurements of peripheral mechanics are able to noninvasive assess the strength of the medial olive-cochlear (MOC) efferent system on outer hair cell function, assess the level dependence of SFOAE fine structure, and account for the performance of normal-hearing listeners and listeners with sensor neural hearing loss in detecting tones in broadband and notched noise. The third aim studies the effects of cochlear no linearity on temporal processing using SFOAE stimulus conditions similar to those used in behavioral experiments on overshoot and amplitude modulation (AM). These experiments will assess the shifts in SFOAEs produced by activation of the MOC system in response to sounds with AM, and will test the extent to which SFOAE measurements can account for measurements of behavioral overshoot in normal listeners and subjects with auditory neuropathy. The results of the proposed experiments will provide useful data and modeling to improve our understanding of the auditory periphery in humans, and may improve our ability to diagnose the magnitude of hearing loss and improve our understanding of the impact of hearing loss on spectral and temporal resolution.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $364,971 )
2008	2008	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	10	2/19/2008	NON-COMPETING CONTINUATION	$364,971
														Subtotal = $364,971

Issue Date FY: 2007 ( Subtotal = $359,005 )
2007	2007	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	9	2/27/2007	NON-COMPETING CONTINUATION	$359,005
														Subtotal = $359,005

Issue Date FY: 2006 ( Subtotal = $358,953 )
2006	2006	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	8	1/27/2006	NON-COMPETING CONTINUATION	$358,953
														Subtotal = $358,953

Issue Date FY: 2005 ( Subtotal = $356,885 )
2005	2005	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	7	1/13/2005	NON-COMPETING CONTINUATION	$356,885
														Subtotal = $356,885

Issue Date FY: 2004 ( Subtotal = $378,372 )
2004	2004	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	6	3/12/2004	COMPETING CONTINUATION	$378,372
														Subtotal = $378,372

Issue Date FY: 2003 ( Subtotal = $278,357 )
2003	2003	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	5		NON-COMPETING CONTINUATION	$278,357
														Subtotal = $278,357

Issue Date FY: 2002 ( Subtotal = $271,862 )
2002	2002	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	4	4/26/2002	NON-COMPETING CONTINUATION	$271,862
														Subtotal = $271,862

Issue Date FY: 2001 ( Subtotal = $267,770 )
2001	2001	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD STREET	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	3	4/24/2001	NON-COMPETING CONTINUATION	$267,770
														Subtotal = $267,770

Issue Date FY: 2000 ( Subtotal = $252,804 )
2000	2000	FATHER FLANAGAN`S BOYS` HOME	13603 Flanagan Blvd.	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	2	8/8/2000	NON-COMPETING CONTINUATION	$252,804
														Subtotal = $252,804

Issue Date FY: 1999 ( Subtotal = $231,762 )
1999	1999	FATHER FLANAGAN`S BOYS` HOME	13603 Flanagan Blvd.	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	1	4/29/1999	NEW	$231,762
														Subtotal = $231,762

Grand Total All Awards = $3,120,741

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ACOUSTIC RESPONSES OF THE HUMAN COCHLEA AND MIDDLE EAR

Award Number: R01DC003784

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/1999

PERIOD OF PERFORMANCE END DATE: 02/28/2009

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