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Coding in Auditory Neurons: Effects of Amino Acids

Award Number: R01DC000151
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1979
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Coding in Auditory Neurons: Effects of Amino Acids - PROJECT SUMMARY Age-related hearing loss (ARHL) is a complex disorder affecting between 50-70% of the United States population aged 65 or older. In public settings, seniors frequently have great difficulty understanding speech, which can lead to withdrawal from social activities, depression and cognitive decline. All individuals and especially the elderly can maintain speech understanding in difficult listening conditions by engaging attentional, cognitive and mnemonic (top-down) resources to help disambiguate speech from a degraded ascending acoustic code. Understanding the impact of aging on circuits that maintain speech understanding and the pharmacology of cholinergic attentional systems in their modulation is at the core of the proposed studies. Studies during the previous grant period identified differential age-related changes in nicotinic cholinergic receptor (nAChR) subunit/subtypes in the medial geniculate body (MGB) and primary auditory cortex (AI). In vitro aging studies detailed the pre- and postsynaptic function of nAChRs in thalamic circuits likely to underpin attentional modulation of acoustic information. Unit recordings from awake rat auditory thalamus MGB also showed age-related repetition-enhancement, as opposed to sensory adaptation, in response to repeating/predictable temporally rich stimuli. This was posited to reflect increased use of corticofugal/higher- order resources. Age-related enhanced coding of repeating modulated stimuli was reproduced in young animals by simply degrading the temporal clarity of the sinusoidal amplitude modulated (SAM) stimuli. Corticothalamic blockade of projections to MGB reversed predictive repetition-enhancement to a degree, but not completely. The proposed Specific Aims will address questions raised by these prior studies and supported by preliminary data. In vitro and in vivo approaches in rats will: SA1: Characterize the functional pharmacology and the impact of aging on nAChR pharmacology in the central and dorsal nuclei of the inferior colliculus (CNIC, ENIC and DNIC). SA2A: Determine single unit response properties of CNIC and DNIC units to temporally distinct and less temporally distinct SAM stimuli presented in repeating/predictable or random sequences. SA2B: Determine the impact of aging on the response properties of CNIC and DNIC units to repeating vs. randomly presented SAM stimuli. SA3. Determine the impact of pontine mesencephalic tegmentum (PMT) release of acetylcholine on the response properties of IC units to temporally distinct and temporally less distinct SAM stimuli presented in a repeating or random sequences. Understanding the mechanisms involved in repetition enhancement/predictive coding and identification of novel nAChR subtypes potentially resistant to aging will inform future behavioral and pharmacotherapeutic approaches to improve speech understanding in the elderly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $559,289 )
2024	2024	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	002	39	1/9/2024	NON-COMPETING CONTINUATION	$503,361
2024	2024	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	003	39	5/3/2024	NON-COMPETING CONTINUATION	$55,928
2024	2023	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	001	38	1/4/2024	COMPETING CONTINUATION	$392,623
2024	2020	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	37	1/4/2024	NON-COMPETING CONTINUATION	-$392,623
														Subtotal = $559,289

Issue Date FY: 2023 ( Subtotal = $643,304 )
2023	2023	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	002	38	1/5/2023	COMPETING CONTINUATION	$643,304
2023	2020	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	001	37	12/29/2022	NON-COMPETING CONTINUATION	$0
2023	2020	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	37	10/31/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $643,304

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	37	10/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $488,912 )
2020	2020	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	001	37	1/15/2020	NON-COMPETING CONTINUATION	$48,892
2020	2020	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	37	11/20/2019	NON-COMPETING CONTINUATION	$440,020
														Subtotal = $488,912

Issue Date FY: 2019 ( Subtotal = $504,735 )
2019	2019	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	36	11/15/2018	NON-COMPETING CONTINUATION	$504,735
														Subtotal = $504,735

Issue Date FY: 2018 ( Subtotal = $520,469 )
2018	2018	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	35	11/3/2017	NON-COMPETING CONTINUATION	$468,423
2018	2018	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	001	35	4/4/2018	NON-COMPETING CONTINUATION	$52,046
														Subtotal = $520,469

Issue Date FY: 2017 ( Subtotal = $521,960 )
2017	2017	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	34	11/8/2016	NON-COMPETING CONTINUATION	$469,763
2017	2017	SOUTHERN ILLINOIS UNIVERSITY	801 N RUTLEDGE ST FL 2	SPRINGFIELD	IL	62702	SANGAMON	USA	Research Related to Deafness and Communication Disorders	001	34	5/24/2017	NON-COMPETING CONTINUATION	$52,197
														Subtotal = $521,960

Issue Date FY: 2016 ( Subtotal = $522,209 )
2016	2016	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	001	33	10/29/2015	COMPETING CONTINUATION	$522,209
2016	2014	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	629016812	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	32	10/23/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $522,209

Issue Date FY: 2014 ( Subtotal = $269,364 )
2014	2014	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	32	7/31/2014	NON-COMPETING CONTINUATION	$269,364
														Subtotal = $269,364

Issue Date FY: 2013 ( Subtotal = $255,897 )
2013	2013	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	31	8/9/2013	NON-COMPETING CONTINUATION	$255,897
														Subtotal = $255,897

Issue Date FY: 2012 ( Subtotal = $269,364 )
2012	2012	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	30	7/26/2012	NON-COMPETING CONTINUATION	$269,364
														Subtotal = $269,364

Issue Date FY: 2011 ( Subtotal = $269,364 )
2011	2011	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	29	7/20/2011	NON-COMPETING CONTINUATION	$269,364
														Subtotal = $269,364

Issue Date FY: 2010 ( Subtotal = $303,864 )
2010	2010	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	001	28	7/21/2010	COMPETING CONTINUATION	-$5,324
2010	2010	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	28	6/7/2010	COMPETING CONTINUATION	$309,188
														Subtotal = $303,864

Issue Date FY: 2006 ( Subtotal = $313,237 )
2006	2006	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	27	5/10/2006	NON-COMPETING CONTINUATION	$313,237
														Subtotal = $313,237

Issue Date FY: 2005 ( Subtotal = $320,775 )
2005	2005	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	COYLER HALL	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	26	5/5/2005	NON-COMPETING CONTINUATION	$320,775
														Subtotal = $320,775

Issue Date FY: 2004 ( Subtotal = $320,775 )
2004	2004	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	COYLER HALL	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	25	5/17/2004	NON-COMPETING CONTINUATION	$320,775
														Subtotal = $320,775

Issue Date FY: 2003 ( Subtotal = $320,775 )
2003	2003	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	COYLER HALL	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	24	5/23/2003	NON-COMPETING CONTINUATION	$320,775
														Subtotal = $320,775

Issue Date FY: 2002 ( Subtotal = $317,044 )
2002	2002	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	COYLER HALL	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	23	6/14/2002	COMPETING CONTINUATION	$317,044
														Subtotal = $317,044

Issue Date FY: 2001 ( Subtotal = $188,810 )
2001	2001	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	COYLER HALL	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	22	6/11/2001	NON-COMPETING CONTINUATION	$188,810
														Subtotal = $188,810

Issue Date FY: 2000 ( Subtotal = $183,307 )
2000	2000	SOUTHERN ILLINOIS UNIVERSITY-CARBONDALE	RESEARCH & PROJECTS FISCAL M	CARBONDALE	IL	62901	JACKSON	USA	Research Related to Deafness and Communication Disorders	000	21	6/12/2000	NON-COMPETING CONTINUATION	$183,307
														Subtotal = $183,307

Grand Total All Awards = $7,444,209

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Coding in Auditory Neurons: Effects of Amino Acids

Award Number: R01DC000151

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1979

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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