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Evaluating the Health Impacts of Interventions to Address Homelessness and Opioid Use Disorder

Award Number: R01DA066715
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Evaluating the Health Impacts of Interventions to Address Homelessness and Opioid Use Disorder - PROJECT SUMMARY People experiencing homelessness are at exceptionally high risk of opioid overdose, severe illness, and premature mortality. As homelessness has risen across the United States, cities are struggling to respond to the overlapping crises of housing instability and opioid use. Although overdose deaths have declined overall since 2022, it remains unclear whether people experiencing homelessness have seen similar reductions or which policies and programs best support their health. Local governments have adopted diverse approaches, including expansion of addiction treatment services, encampment clearances, and low-threshold housing models for people exiting encampments, yet rigorous evidence on their real-world health impact remains limited. This project will leverage the Massachusetts Public Health Data Warehouse, a comprehensive state- wide resource linking medical services, emergency medical encounters, medications for opioid use disorder, substance use treatment admissions, mortality, and incarceration records. Through a partnership with the City of Boston and the Massachusetts Department of Public Health, these statewide health data have been linked to homelessness service and housing placement records, enabling real-world evaluation of municipal policies and program models for people experiencing homelessness who use opioids. We will (1) characterize longitudinal trends in overdose, health service use, and housing engagement among people experiencing homelessness from 2015–2024 across major policy actions; (2) assess associations between homelessness programs and overdose and health outcomes; and (3) examine the effects of low-threshold housing placement for people exiting encampments—including transitions to permanent housing or program closure—using quasi- experimental approaches. This study will provide a comprehensive evaluation of how urban homelessness policies and housing programs influence overdose and health in the fentanyl era. Findings will offer actionable evidence to guide municipal and state decision-making, inform homelessness and addiction service delivery, and support efforts to improve health among people experiencing homelessness.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $796,649 )
2026	2026	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	1	6/29/2026	NEW	$0
2026	2026	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	1	6/9/2026	NEW	$796,649
														Subtotal = $796,649

Grand Total All Awards = $796,649

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Evaluating the Health Impacts of Interventions to Address Homelessness and Opioid Use Disorder

Award Number: R01DA066715

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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