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PROTECT: Prevention and Remote Outreach for Treatment and Engagement in Care through Telehealth

Award Number: R01DA064978
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2026
PERIOD OF PERFORMANCE END DATE: 12/31/2030

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PROTECT: Prevention and Remote Outreach for Treatment and Engagement in Care through Telehealth - People involved in the criminal legal system (CLS) experience disproportionately high risk for exposure to HIV, yet access to PrEP for HIV prevention remains severely limited, particularly in jail settings. Standard approaches, such as education and passive referrals, have proven ineffective in engaging recently released individuals in PrEP care, highlighting the need for targeted interventions to promote continuity of care. To close this gap, we propose testing the Comprehensive Tele-Health concieRge (C-THR) model, a telehealth-based, peer-driven intervention proposed to improve PrEP initiation and retention among people with histories of drug use exiting county jails. C-THR applies patient-centered care at multiple levels: (1) System-level; (2) Interpersonal-level; and (3) Individual-level. C-THR has already demonstrated high acceptability, feasibility, and preliminary efficacy in improving HIV viral suppression and retention on buprenorphine among individuals with opioid use disorder. This randomized controlled trial (RCT) will assess the efficacy, cost-effectiveness, and implementation feasibility of C-THR to inform scalable, evidence-based approaches for increasing PrEP access for people in jail. The specific aims are: Aim 1: Evaluate the efficacy of C-THR compared to standard of care (patient navigation) in improving PrEP adherence and persistence (primary outcome; tenofovir detection in urine samples) and drug treatment engagement (secondary outcome; participation in medications for opioid use disorder, other pharmacotherapies, cognitive behavioral therapy, or group counseling). Aim 2: Conduct an economic evaluation of C-THR, assessing both budgetary impact and cost-effectiveness to inform future local and national implementation efforts. Aim 3: Identify key facilitators to C-THR implementation and evaluate how these factors influence fidelity, reach, and overall effectiveness, ensuring that findings can be translated into sustainable policy and practice. This study will provide critical insights into the scalability and effectiveness of telehealth models in increasing PrEP uptake and improving continuity of care for CLS-involved populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $677,248 )
2026	2026	UNIVERSITY OF MIAMI	1320 SOUTH DIXIE HIGHWAY STE 650	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Drug Use and Addiction Research Programs	000	1	2/13/2026	NEW	$677,248
														Subtotal = $677,248

Grand Total All Awards = $677,248

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PROTECT: Prevention and Remote Outreach for Treatment and Engagement in Care through Telehealth

Award Number: R01DA064978

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2026

PERIOD OF PERFORMANCE END DATE: 12/31/2030

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