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Matching Treatments to Cognitive Deficits in Offenders with Substance Use Disorders

Award Number: R01DA058004
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Matching Treatments to Cognitive Deficits in Offenders with Substance Use Disorders - Project Summary/Abstract Prior research has identified two subtypes of antisocial offenders, typified by distinct dysfunctional cognitive- emotion interactions undermining self-regulation. One subtype is characterized by an attention-based abnormality, which impairs adaptive processing of contextual information, tangential to one’s primary focus. This abnormality is typified by offenders with high levels of callous/unemotional traits. A second subtype is characterized by hyper-reactions to personally relevant cues, interfering with executive functions that are otherwise needed to regulate behavior. This abnormality is prevalent in those with high externalizing characteristics. Our team has developed cognitive skills training that addresses each of these specific deficits in distinct ways. These distinct interventions are intended to address mechanism-specific cognitive emotional dysfunction, as opposed to treating distinct dysfunctions with a uniform approach. Under an R21, our pilot work has shown evidence of improving outcomes in offenders by matching specific deficits with focused skills training. Here we seek to conduct a well-powered, randomized clinical trial to demonstrate reliability and generalizability of these effects. We expect to verify prior findings of improved outcomes by matching individual deficits with the targeted interventions. We will examine effects of treatment on specific cognitive skills (assessed by laboratory- based tests) and real-world behavioral outcomes including substance use behaviors, institutional adjustment, and recidivism following release from prison. Further, we will examine advanced neuroimaging measures to assess brain changes with treatment. This will aid in specifying potentially different mechanisms of treatment success in each respective group. This project addresses the ongoing need to improve and validate focused interventions that target specific deficits, replacing less-effective one-size-fits-all approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $788,790 )
2025	2025	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Drug Use and Addiction Research Programs	001	2	5/29/2025	NON-COMPETING CONTINUATION	$788,790
2025	2024	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	1	12/5/2024	NEW	$0
														Subtotal = $788,790

Issue Date FY: 2024 ( Subtotal = $812,460 )
2024	2024	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	2425 RIDGECREST DR SE	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	1	9/16/2024	NEW	$812,460
														Subtotal = $812,460

Grand Total All Awards = $1,601,250

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Matching Treatments to Cognitive Deficits in Offenders with Substance Use Disorders

Award Number: R01DA058004

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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