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Investing in Prevention Infrastructure: Economic Evaluation of the PROSPER System

Award Number: R01DA057996
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Investing in Prevention Infrastructure: Economic Evaluation of the PROSPER System - Project Summary The proposed study will evaluate the economic impact of a major NIDA-funded prevention delivery and support system for evidence-based preventive interventions (EBPIs) known as PROSPER (PROmoting School/community-university Partnerships to Enhance Resilience). This research will build on the existing randomized trial of PROSPER that delivered EBPIs to over 12,000 youth in rural communities 18 to 20 years ago and cultivated sustained high-quality local prevention efforts. These community prevention teams selected and implemented family-focused and school-based EBIs for middle school students in 6th and 7th grade. Initial assessments followed students from pretest (6th grade) through 12th grade (five years post-intervention). Prior funded research pointed to consistent findings for reduced substance misuse among intervention participants. These earlier findings warrant further investigation of the economic implications. Consequently, the proposed study will allow us to assess how long-term effects of the intervention will translate into economic benefits through adulthood. Beyond estimating the full economic impact of the PROSPER system, we will also assess how local program implementation and supportive systemic factors may influence the efficiency of universal prevention efforts, providing needed information around how to build efficient substance abuse prevention efforts. The specific aims of this study are to: (1) Evaluate the economic impact of the PROSPER model for preventing substance misuse; (2) Model how variation in local prevention infrastructure influences economic impact; and (3) Assess how individual risk factors impact prevention efficiency. Prior work demonstrated how the resources necessary for program delivery can be managed more efficiently within a prevention delivery system that cultivates sustainable funding streams to support long-term dissemination. The proposed research would follow this investigation by evaluating how these increased efficiencies can improve the likelihood for positive economic benefit resulting from intervention effectiveness. Importantly, this inquiry will examine the range of expected economic outcomes given variation in implementation factors for program delivery, leveraging unique detailed data assessing this. Further, investigations of how economic impact may vary due to participant characteristics will further inform policy makers of the range of outcomes that could be expected. Thus, this research provides a unique opportunity to determine the long-term economic benefit from an efficient prevention delivery system’s impact on reduced substance misuse and risky behavior among adolescents.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $693,536 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Use and Addiction Research Programs	000	3	3/26/2025	NON-COMPETING CONTINUATION	$624,184
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Use and Addiction Research Programs	001	3	4/11/2025	NON-COMPETING CONTINUATION	$69,352
														Subtotal = $693,536

Issue Date FY: 2024 ( Subtotal = $683,168 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Use and Addiction Research Programs	001	2	3/15/2024	NON-COMPETING CONTINUATION	$614,852
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Use and Addiction Research Programs	002	2	5/1/2024	NON-COMPETING CONTINUATION	$68,316
2024	2023	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Use and Addiction Research Programs	000	1	2/27/2024	NEW	$0
														Subtotal = $683,168

Issue Date FY: 2023 ( Subtotal = $683,168 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Use and Addiction Research Programs	000	1	5/11/2023	NEW	$683,168
														Subtotal = $683,168

Grand Total All Awards = $2,059,872

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Investing in Prevention Infrastructure: Economic Evaluation of the PROSPER System

Award Number: R01DA057996

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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