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Weighting Longitudinal Data to Access Opioid Analgesia Tapering Outcomes among Patients with Co-occurring Chronic Pain and Substance Use Disorder

Award Number: R01DA057658
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Weighting Longitudinal Data to Access Opioid Analgesia Tapering Outcomes among Patients with Co-occurring Chronic Pain and Substance Use Disorder - Chronic pain and substance use disorder (SUD), including opioid use disorder (OUD), frequently co-occur and create complex clinical decisions involving opioid analgesic tapering, medications for opioid use disorder (MOUD), and multidisciplinary pain treatment. Although opioid tapering has been widely implemented, limited evidence exists on outcomes associated with tapering when paired with MOUD transition or multidisciplinary pain care among patients with chronic pain and co-occurring SUD/OUD. Individual healthcare systems often include relatively small numbers of patients with these combined conditions, and key outcomes such as overdose, suicide/self-harm, and hospitalization may occur in low total numbers. As a result, large real-world data resources and reproducible analytic methods are needed to evaluate treatment approaches and measurable clinical outcomes. This project will create and validate analytic weights for the Cerner Real-World database, which includes electronic health record data from more than 100 million unique U.S. patients across participating hospitals and clinics. Using American Hospital Association and U.S. Census data, we will develop weights stratified by hospital characteristics and adjusted by relevant population descriptors. We will validate the weighting scheme by comparing weighted estimates from the Cerner Real-World database with estimates from the Nationwide Inpatient Sample for chronic pain, SUD/OUD, overdose diagnoses, hospitalizations, and relevant multidisciplinary pain interventions for the years 2000-2025. We will then use weighted retrospective cohort analyses to examine associations between opioid tapering, MOUD transition, multidisciplinary pain treatment, and subsequent risk of overdose, suicide/self-harm, and other hospitalizations among patients with chronic pain and co-occurring SUD/OUD. Heterogeneity analyses will be limited to pre-specified, clinically relevant patient and treatment characteristics when scientifically justified and adequately powered. The project will produce a validated real-world data resource and generate evidence about treatment approaches for patients with chronic pain and co-occurring SUD/OUD. Results will inform evidence-based decisions regarding opioid tapering, MOUD transition, and multidisciplinary pain treatment using objective health outcomes directly relevant to patient care and public health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $678,239 )
2026	2026	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Drug Use and Addiction Research Programs	001	3	7/24/2026	NON-COMPETING CONTINUATION	$678,239
2026	2022	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Drug Use and Addiction Research Programs	000	1	3/19/2026	NEW	$0
														Subtotal = $678,239

Issue Date FY: 2025 ( Subtotal = $680,457 )
2025	2025	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Drug Use and Addiction Research Programs	000	2	8/7/2025	EXTENSION WITH OR WITHOUT FUNDS	$680,457
														Subtotal = $680,457

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Drug Use and Addiction Research Programs	000	1	11/29/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,093,521 )
2022	2022	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Drug Use and Addiction Research Programs	000	1	9/21/2022	NEW	$2,093,521
														Subtotal = $2,093,521

Grand Total All Awards = $3,452,217

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Weighting Longitudinal Data to Access Opioid Analgesia Tapering Outcomes among Patients with Co-occurring Chronic Pain and Substance Use Disorder

Award Number: R01DA057658

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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