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Early Adversity and Drug Use Vulnerability Among Low Income Rural Children: Testing a Neuro-ecological Model of Resilience

Award Number: R01DA055630
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary This diversity supplement provides doctoral training for Ms. Avary Evans within the Building Resilience and Nurturing Children's Health (BRANCH; R01DA055630) study. BRANCH investigates the influence of rural environments on neurobehavioral vulnerabilities to drug use. Children in rural areas face higher addiction risk due to socioeconomic and resource disparities that affect their development. The study collects comprehensive data on 250 children starting at age 7, using fMRI to assess reward sensitivity, biospecimens to evaluate stress biology, and various measures of risk and protective processes. The supplement supports Ms. Evans, a doctoral student at the University of Georgia, to examine neuroendocrine processes influencing the development of reward sensitivity. Reward sensitivity, a significant predictor of drug use vulnerability, undergoes notable changes during pubertal maturation starting with adrenarche (ages 7-9). This work aims to clarify the influence of adrenarcheal timing on reward sensitivity and how socioeconomic hardship (SES-H) moderates this relationship. The first aim is to investigate how adrenarcheal timing, measured via dehydroepiandrosterone (DHEA) levels, predicts activation in the reward network during a task 18 months later. The second aim is to explore how SES-H amplifies the relationship between early adrenarche and reward sensitivity. Ms. Evans will receive training to integrate hormonal data with developmental hypotheses, understand addiction neuroscience, conduct data analysis, and pursue professional development. This supplement aims to empower Ms. Evans with the necessary skills to excel in her career as an independent addiction scientist.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $706,674 )
2024	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	001	2	4/26/2024	NON-COMPETING CONTINUATION	$67,936
2024	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	2	1/18/2024	NON-COMPETING CONTINUATION	$611,416
2024	2024	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	002	2	8/5/2024	SUPPLEMENT FOR EXPANSION	$27,322
														Subtotal = $706,674

Issue Date FY: 2023 ( Subtotal = $666,580 )
2023	2023	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	1	3/29/2023	NEW	$666,580
														Subtotal = $666,580

Grand Total All Awards = $1,373,254

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Early Adversity and Drug Use Vulnerability Among Low Income Rural Children: Testing a Neuro-ecological Model of Resilience

Award Number: R01DA055630

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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