Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Real time relapse risk scoring for Opioid Use Disorder (OUD) from clinical trial datasets

Award Number: R01DA055610
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

Group Awards By:

View Award Description

Real time relapse risk scoring for Opioid Use Disorder (OUD) from clinical trial datasets - Real time relapse risk scoring for Opioid Use Disorder (OUD) from clinical trial datasets Project Summary Any clinician treating a patient with Opioid Use Disorder (OUD) would like to know whether this patient would relapse in the next week or month. Such a score, analogous to a credit score in consumer finance, may be similarly obtained from longitudinal data streams derived from patient behavior during SUD treatment. There are several common data sources that every OUD patient in treatment produces: a binary, longitudinal data survey of use patterns for a set of pre-determined substances of abuse, treatment session attendance records, and medication records. In particular, urine drug screens (UDS) or alcohol and nicotine breathalyzers and standard Timeline Follow Back (TLFB) questionnaires are universal surveys in every treatment delivery context, including large pragmatic clinical trials. While these data streams are incomplete, of different lengths and sampling frequencies, and correlate in complex ways, contemporary machine learning methods allow us to overcome these challenges. We aim to build a toolbox that would allow for the following: 1) standardized methods for risk scoring and visualization from UDS and TLFB datasets in existing large clinical trials; 2) standard methods for inferences of risk scores: procedure for hypothesis testing whether an intervention made a difference in the risk scores and their trajectories. 3) user-friendly software modules aimed toward researchers and administrators for quality improvement projects and customized predictive modeling pipelines, and interpretable web portal for clinicians, analogous to a credit report. This proposal will also incorporate usability survey and evaluation for algorithmic bias. These applications will provide a computational framework for future real time predictive modeling work for many other different substance use disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $669,094 )
2026	2026	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Drug Use and Addiction Research Programs	000	4	6/18/2026	NON-COMPETING CONTINUATION	$669,094
														Subtotal = $669,094

Issue Date FY: 2025 ( Subtotal = $650,581 )
2025	2025	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Drug Use and Addiction Research Programs	001	3	7/10/2025	NON-COMPETING CONTINUATION	$650,581
2025	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Drug Use and Addiction Research Programs	000	2	11/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $650,581

Issue Date FY: 2024 ( Subtotal = $658,442 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Drug Use and Addiction Research Programs	000	2	6/12/2024	NON-COMPETING CONTINUATION	$658,442
														Subtotal = $658,442

Issue Date FY: 2023 ( Subtotal = $683,378 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	7/21/2023	NEW	$683,378
														Subtotal = $683,378

Grand Total All Awards = $2,661,495

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Real time relapse risk scoring for Opioid Use Disorder (OUD) from clinical trial datasets

Award Number: R01DA055610

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer