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Clinic-level implementation of mHealth to improve HIV viral suppression for patients with substance use disorders

Award Number: R01DA055527
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Clinic-level implementation of mHealth to improve HIV viral suppression for patients with substance use disorders - PROJECT SUMMARY / ABSTRACT In response to PAR-20-036: Getting to Zero: Understanding HIV Viral Suppression and Transmission in the United States, we propose a hybrid type 2 effectiveness-implementation study that will evaluate an innovative clinic-level intervention featuring an evidence-based mobile health (mHealth) application (CHESS) and peer- driven social support. Within the infrastructure of a large HIV/AIDS Service Organization offering an integrated, patient-centered model of care in Colorado, Missouri, Texas and Wisconsin, we will implement an mHealth system designed to close information gaps, build intrinsic motivation, and develop behavioral skills needed for sustained adherence to treatment. Peer support will be provided through activities delivered by patients recruited and trained to serve as peer mentors. The mHealth system and peer mentoring will be integrated into the existing care model, known as the HIV Medical Home. We hypothesize that the integrated intervention will increase the proportion of patients with viral suppression and reduce missed clinic appointments by supporting three needs: (1) It will facilitate real-time, community-based capture of data reflecting social and behavioral determinants known to precede lapses in HIV care (e.g., housing and food insecurity, unhealthy alcohol or drug use, or poor medication adherence); (2) It will improve engagement in care by increasing social connectedness among patients, and between patients and peer mentors; and (3) It will support retention in addiction treatment and mental health care that help maintain engagement in HIV care. Project Year 1 will be devoted to planning and refinement of the intervention in close collaboration with organizational leaders and people living with HIV who are members of the local communities. Beginning in Project Year 2, we will conduct a stepped wedge cluster randomized trial of the intervention in seven clinics. We will leverage data collected through the integrated electronic health record system serving all seven clinics to test intervention effectiveness on viral suppression and retention in care. We also will conduct an implementation cost analysis and cost-effectiveness analysis to inform future sustainment of the intervention model. The study builds on a solid foundation of prior research demonstrating the promise of mHealth and peer strategies for enhancing engagement in HIV and addiction treatment and care for other complex conditions. The findings from this study, if successful, will contribute a new and innovative set of tools with high potential impact for improving HIV viral suppression in multiple geographic settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $612,888 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	001	4	4/10/2025	NON-COMPETING CONTINUATION	$61,288
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	000	4	2/14/2025	NON-COMPETING CONTINUATION	$551,600
														Subtotal = $612,888

Issue Date FY: 2024 ( Subtotal = $617,236 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	002	3	4/25/2024	NON-COMPETING CONTINUATION	$61,723
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	001	3	2/23/2024	NON-COMPETING CONTINUATION	$555,513
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	000	2	11/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $617,236

Issue Date FY: 2023 ( Subtotal = $620,697 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	000	2	2/13/2023	NON-COMPETING CONTINUATION	$620,697
														Subtotal = $620,697

Issue Date FY: 2022 ( Subtotal = $741,799 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	001	1	4/21/2022	NEW	$0
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Drug Use and Addiction Research Programs	000	1	4/12/2022	NEW	$741,799
														Subtotal = $741,799

Grand Total All Awards = $2,592,620

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Clinic-level implementation of mHealth to improve HIV viral suppression for patients with substance use disorders

Award Number: R01DA055527

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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