Thursday, March 12, 2026 3/12/2026

Assessing the Impact of Cannabis Legalization on Adolescent Cannabis Use and Cannabis-Related Health Conditions

Award Number: R01DA053192
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Assessing the Impact of Cannabis Legalization on Adolescent Cannabis Use and Cannabis-Related Health Conditions - PROJECT SUMMARY/ABSTRACT Adolescent cannabis use is increasingly recognized as an important public health problem with significant adverse health consequences. Recreational cannabis legalization (RCL) has high potential to increase risk for adolescent cannabis use and cannabis-related health conditions. However, the effects of RCL on adolescents are unknown. With a highly representative sample of nearly 1 million adolescents (N=900,000) regularly screened for cannabis use in Kaiser Permanente Northern California’s large integrated healthcare delivery system from 2015 to 2023, this multi-method study will address the pressing public health questions of whether and how California state RCL and heterogeneity of local regulatory schemes impact the risk of adolescent cannabis use and cannabis-related health conditions. We will use a quasi-experimental interrupted time series design to test whether adolescent cannabis use, cannabis-related health conditions (e.g., cannabis use disorder, other substance use, respiratory symptoms, mental health problems, cannabis-related accidents, acute cannabis intoxication, cannabinoid hyperemesis syndrome), and cannabis-related healthcare use (e.g., emergency department, addiction treatment) and rise post-RCL. We will also examine local RCL policies (retailer bans or caps, product and advertising restrictions, taxes, health warnings) and use geographic information systems methods to map retailer location (e.g., distance from home address to the closest retailer) onto individual-level electronic health record data collected in clinical care to test whether the effects of RCL are stronger among those who live in communities with less restrictive local policies, adjusting for pre-RCL medical cannabis policies. We will conduct hypothesis-driven moderation analyses to identify sub-groups whose risk for cannabis use and cannabis-related health conditions may be greatest following RCL. To gain further clinical insight into our quantitative data and guide next steps, we will conduct focus groups with adolescents and interviews with addiction medicine clinicians, pediatricians, and emergency department physicians to gain insight into how RCL impacts adolescent cannabis use and addiction treatment need from the perspective of both patients and providers. Together, results will have immediate public health and clinical implications, providing urgently needed data to identify potentially actionable areas for future policy adaptations and aid decision making for public health practices to reduce adolescent cannabis use and cannabis-related harms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $651,068 )
2026	2026	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	5	2/13/2026	NON-COMPETING CONTINUATION	$651,068
														Subtotal = $651,068

Issue Date FY: 2025 ( Subtotal = $649,431 )
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	4	3/20/2025	NON-COMPETING CONTINUATION	$584,488
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	001	4	4/10/2025	NON-COMPETING CONTINUATION	$64,943
														Subtotal = $649,431

Issue Date FY: 2024 ( Subtotal = $627,546 )
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	001	3	4/26/2024	NON-COMPETING CONTINUATION	$62,755
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	3	2/13/2024	NON-COMPETING CONTINUATION	$564,791
														Subtotal = $627,546

Issue Date FY: 2023 ( Subtotal = $690,081 )
2023	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	2	1/26/2023	NON-COMPETING CONTINUATION	$690,081
														Subtotal = $690,081

Issue Date FY: 2022 ( Subtotal = $719,065 )
2022	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	1	3/8/2022	NEW	$719,065
														Subtotal = $719,065

Grand Total All Awards = $3,337,191

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Assessing the Impact of Cannabis Legalization on Adolescent Cannabis Use and Cannabis-Related Health Conditions

Award Number: R01DA053192

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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