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Plasticity of Aversive Salience in Opioid Use Disorder

Award Number: R01DA050677
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Plasticity of Aversive Salience in Opioid Use Disorder - ABSTRACT/PROJECT SUMMARY NOT-DA-20-012 Given that deaths linked to opioid addiction are at an all-time high in the United States, there is a crucial need to understand brain mechanisms impeding versus promoting recovery, a process marked by prolonged abstinence and use of internal/external resources to resolve drug problems. The broad aims of this proposal are to understand how brain circuitry implicated in the salience of aversive internal (bodily signals) and external (stressful, loss) stimuli tracks recovery within and across individuals with opioid addiction to (1) inform future targets for intervention (e.g., brain neurofeedback); and (2) aid the development of individualized treatment to reduce drug-related deaths. Within three months of treatment, 50% of substance users relapse, taking drugs to avoid aversive bodily states linked to craving, withdrawal, and stress. Our preliminary data suggest that opioid users show greater negative affect, higher intensity of internal sensations, and faster pain reactivity than healthy controls, paired with lower salience- relevant brain responses during attention to bodily signals and anticipation of monetary losses However, it is unclear whether aversive salience-related brain circuitry improves and tracks recovery during the vulnerable first three months during treatment. The specific aims of this proposal test how salience-based brain circuitry differs between 200 treatment-seeking individuals with opioid use disorder and 50 healthy individuals at four timepoints during early opioid recovery (2 weeks and 1, 2, and 3 months), identifying what self-report, behavioral, and brain variables can be used to identify opioid users at high risk for relapse versus those who maintain abstinence. Functional magnetic resonance imaging (fMRI) paradigms involving bodily awareness, monetary win/loss, and stress/drug cues, substance use assessments, and NIDA self-report/behavioral phenotyping batteries will be collected at each timepoint. Once the proposed aims are completed, the findings from this dataset will be evaluated to determine whether these prediction metrics can be validated in additional treatment-seeking samples.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $282,476 )
2025	2025	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	001	5	4/7/2025	NON-COMPETING CONTINUATION	$28,248
2025	2025	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	000	5	11/18/2024	NON-COMPETING CONTINUATION	$254,228
														Subtotal = $282,476

Issue Date FY: 2024 ( Subtotal = $725,709 )
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	001	4	4/24/2024	NON-COMPETING CONTINUATION	$72,571
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	000	4	12/22/2023	NON-COMPETING CONTINUATION	$653,138
														Subtotal = $725,709

Issue Date FY: 2023 ( Subtotal = $653,620 )
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	001	3	1/26/2023	NON-COMPETING CONTINUATION	$65,363
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	000	3	12/15/2022	NON-COMPETING CONTINUATION	$588,257
														Subtotal = $653,620

Issue Date FY: 2022 ( Subtotal = $646,149 )
2022	2022	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	001	2	3/24/2022	NON-COMPETING CONTINUATION	$64,615
2022	2022	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	000	2	12/14/2021	NON-COMPETING CONTINUATION	$581,534
														Subtotal = $646,149

Issue Date FY: 2021 ( Subtotal = $648,878 )
2021	2021	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Drug Use and Addiction Research Programs	000	1	2/26/2021	NEW	$648,878
														Subtotal = $648,878

Grand Total All Awards = $2,956,832

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Plasticity of Aversive Salience in Opioid Use Disorder

Award Number: R01DA050677

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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