Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Screen, Treat and Retain Meth-Using People with Opioid Use Disorders at MMT Clinics (STAR-OM)

Award Number: R01DA050486
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2025

Group Awards By:

View Award Description

Screen, Treat and Retain Meth-Using People with Opioid Use Disorders at MMT Clinics (STAR-OM) - Research Abstracts We propose to develop and evaluate optimal combinations of evidence-based interventions (EBIs) to improve HIV outcomes and reduce methamphetamine use among people with opioid use disorder (OUD) who are in methadone maintenance therapy (MMT) in Vietnam (STAR-OM study). Over the past decade, the expansion of MMT has contributed to stemming both HIV and opioid epidemics. However, rising methamphetamine use threatens these achievements. The twinned epidemics of opioid and methamphetamine use have also been reported in the US and other countries. Building on our pilot work with MMT patients in Hanoi, through collaborative work with local MMT providers and patients, we will refine adapted EBIs to develop an adaptive design that offers an individualized approach to treatment. The adaptive design includes: (1) Two frontline interventions: 6 weeks of CM then 6 weeks of weekly group educational sessions (low intensity CM) and 12 weeks of CM (high intensity CM); (2) One (short-term) tailoring outcome: urine tests negative with meth metabolites in both week 11 and 12 are considered responsive to frontline interventions; (3) Three alternative interventions: those with positive outcomes will move to 12-week maintenance stage and receive two daily SMS reminders plus one weekly self-monitoring assessment message. Non-responders will move to 12-week enhanced treatment stage and are randomized to either Matrix group counseling only or Matrix group counseling plus CM. We will compare effectiveness of two frontline interventions and four adaptive interventions with a Sequential Multiple Assignment Randomization Trial in 200 HIV+ (150 from HCMC; 50 from Hanoi) and 400 HIV- (200 from each city) MMT patients who report moderate- and high-risk meth use on self-screening with tablet-based ASSIST and/or have urine positive with methamphetamine metabolites. In each location, the study will stratify participants by HIV status before randomizing them to one of two frontline interventions. Primary outcomes - including HIV viral suppression, HIV risk behaviors, and meth use (reported and urine tests) - will be assessed at 12, 24 and 48 weeks. We will calculate the incremental cost effectiveness ratio (ICER) comparing cost-effectiveness between two frontline interventions as well as among four adaptive strategies. Finally yet importantly, we also conduct ethnographic observations and in-depth interviews with MMT clinic managers, clinical staff and MMT patients (N=60, 30 per city) to identify structural, provider and patient-level factors that influence adoption and scale-up of the adaptive interventions. Findings from this study with Type I Hybrid design to evaluate EFFECTIVENESS-Implementation will provide valuable evidence to develop treatments in resourced and resourced-constrained settings to confront the twinned epidemics of opioid and methamphetamine use in the context of surging HIV epidemic due to drug abuse.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	Drug Use and Addiction Research Programs	000	5	8/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $459,537 )
2024	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	Drug Use and Addiction Research Programs	000	5	3/22/2024	NON-COMPETING CONTINUATION	$323,694
2024	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	Drug Use and Addiction Research Programs	002	5	8/29/2024	SUPPLEMENT FOR EXPANSION	$99,877
2024	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	Drug Use and Addiction Research Programs	001	5	4/30/2024	NON-COMPETING CONTINUATION	$35,966
														Subtotal = $459,537

Issue Date FY: 2023 ( Subtotal = $422,470 )
2023	2023	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	Drug Use and Addiction Research Programs	000	4	3/24/2023	NON-COMPETING CONTINUATION	$422,470
														Subtotal = $422,470

Issue Date FY: 2022 ( Subtotal = $474,840 )
2022	2022	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	Drug Use and Addiction Research Programs	000	3	7/22/2022	NON-COMPETING CONTINUATION	$474,840
														Subtotal = $474,840

Issue Date FY: 2021 ( Subtotal = $473,025 )
2021	2021	HANOI MEDICAL UNIVERSITY	1 TON THAT TUNG STREET,	HA NOI	HA NOI			VNM	Drug Use and Addiction Research Programs	001	2	5/13/2021	NON-COMPETING CONTINUATION	$473,025
2021	2020	HANOI MEDICAL UNIVERSITY	1 TON THAT TUNG STREET,	HA NOI	HA NOI			VNM	Drug Use and Addiction Research Programs	000	1	3/24/2021	NEW	$0
														Subtotal = $473,025

Issue Date FY: 2020 ( Subtotal = $476,502 )
2020	2020	HANOI MEDICAL UNIVERSITY	TON THAT TUNG,	HANOI				VNM	Drug Use and Addiction Research Programs	001	1	6/24/2020	NEW	$0
2020	2020	HANOI MEDICAL UNIVERSITY	TON THAT TUNG,	HANOI				VNM	Drug Use and Addiction Research Programs	000	1	5/26/2020	NEW	$476,502
														Subtotal = $476,502

Grand Total All Awards = $2,306,374

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Screen, Treat and Retain Meth-Using People with Opioid Use Disorders at MMT Clinics (STAR-OM)

Award Number: R01DA050486

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer