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A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers

Award Number: R01DA049238
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers - Project Summary/Abstract Substance use behavior (smoking/drinking) is well known to be the result of a complex interplay between genetics and environmental components. However macro- and micro-environmental effects on smoking and drinking behavior are still poorly understood and there is little work evaluating the relationship of such factors to neurobiological changes measured via brain imaging. The data are available though. There is a great amount of internationally collected imaging and genomics data, however much of this data is not being analyzed due to privacy issues or other factors which prevent sharing of the raw data. To address this barrier, we propose to leverage and extend a software platform which enables decentralized analysis of data (e.g. sharing without sharing). We will use this platform to perform an analysis which pools together data from the 10,000 participant longitudinal US-based adolescent brain cognitive development (ABCD) study with an international cohort of more than 20,000 participants from Europe, China, and India called the global imaging genetics of adolescents (GIGA). Our focus will be on assessing macro- and micro-environmental and heritability factors associated with sub- stance use behavior as well as their neuronal biomarkers in the context of factors such as cultural acceptance, urbanization, annual household income, and climate. Results will provide new insights into the factors contrib- uting to substance use behavior. We also propose to develop a persistent decentralized analysis nodes for the GIGA sites using our Collaborative Informatics and Neuroimaging Suite Toolkit for Anonymous Computation (COINSTAC) to allow for re-analyses of these large cohorts as well as pooling with one’s local data without requiring collocation of the data at the same site. 3


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$233 )
2026	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	5	12/29/2025	NON-COMPETING CONTINUATION	-$233
														Subtotal = -$233

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	5	7/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $542,744 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	5	6/15/2023	NON-COMPETING CONTINUATION	$542,744
														Subtotal = $542,744

Issue Date FY: 2022 ( Subtotal = $542,744 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	4	6/14/2022	NON-COMPETING CONTINUATION	$542,744
														Subtotal = $542,744

Issue Date FY: 2021 ( Subtotal = $542,744 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	3	7/2/2021	NON-COMPETING CONTINUATION	$542,744
														Subtotal = $542,744

Issue Date FY: 2020 ( Subtotal = $691,037 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	003	2	7/24/2020	SUPPLEMENT FOR EXPANSION	$149,834
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	002	2	6/18/2020	NON-COMPETING CONTINUATION	$541,203
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	001	1	2/6/2020	NEW	$551,746
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	1	2/5/2020	NEW	-$551,746
														Subtotal = $691,037

Issue Date FY: 2019 ( Subtotal = $551,746 )
2019	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	1	9/3/2019	NEW	$551,746
														Subtotal = $551,746

Grand Total All Awards = $2,870,782

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A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers

Award Number: R01DA049238

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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