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Impact of in utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study

Award Number: R01DA048033
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Impact of in utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study - ABSTRACT Marijuana use during pregnancy is increasing rapidly in the US. The spreading legalization and growing acceptance, accessibility, and use of marijuana during pregnancy raise important public health concerns for pregnant women as our understanding of the developmental, behavior, and mental health impacts on children exposed to marijuana in utero is alarmingly inadequate. To address this critical research gap, we propose a longitudinal birth cohort study of over 420,000 children born between 2010-2021 at Kaiser Permanente Northern California (KPNC) hospitals. We will leverage data from KPNC's comprehensive electronic health records (EHR) and unique universal prenatal drug use screening program which screens 40,000 women annually via “gold standard” self-report and urine toxicology tests for marijuana and other substance use. As part of standard care, all children are universally screened for developmental delays at well-child visits and as they grow older universal mental health screening captures depression and substance use disorders. Information on child neurodevelopment, behavior and mental health screening outcomes and diagnoses will be ascertained from KPNC's EHR and through linkage to California's Department of Developmental Services. We will ascertain information on important confounders (e.g., maternal mental health, maternal age, tobacco and other substance use, preterm delivery) from KPNC's EHR. Children born to women with singleton gestations who are screened for prenatal marijuana and other substance use will be included. We will evaluate associations between prenatal marijuana exposure and the risk of neurodevelopmental impairments, behavioral disorders, and mental health outcomes from birth to 13 years of age, after accounting for potential confounders. We will also test for sex differences in these associations. Additional analyses will assess the effects in children whose mothers screened positive for marijuana only during pregnancy (i.e., no other prenatal substance use). The proposed study leverages a diverse population, and with high generalizability, will be the largest to date. Findings will have significant public health and clinical implications and can be used by women to make informed decisions about marijuana use during pregnancy. Additionally, the study cohort will be a valuable resource for future research on the longer-term impact of prenatal marijuana use on children's health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $579,276 )
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	5	5/6/2025	NON-COMPETING CONTINUATION	$579,276
														Subtotal = $579,276

Issue Date FY: 2024 ( Subtotal = $637,562 )
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	4	5/3/2024	NON-COMPETING CONTINUATION	$637,562
														Subtotal = $637,562

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	3	4/26/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $648,284 )
2022	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	3	4/15/2022	NON-COMPETING CONTINUATION	$648,284
														Subtotal = $648,284

Issue Date FY: 2021 ( Subtotal = $652,568 )
2021	2021	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	2	4/20/2021	NON-COMPETING CONTINUATION	$652,568
														Subtotal = $652,568

Issue Date FY: 2020 ( Subtotal = $581,449 )
2020	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	001	1	7/10/2020	NEW	$0
2020	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	1	6/30/2020	NEW	$581,449
														Subtotal = $581,449

Grand Total All Awards = $3,099,139

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Impact of in utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study

Award Number: R01DA048033

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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