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ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next Steps

Award Number: R01DA047119
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next Steps - PROJECT SUMMARY The ENIGMA consortium was established to investigate brain structure, function, and disease by combining genomic and neuroimaging datasets from multiple sites. Its cost-effective goal is to maximize statistical power and the yield from existing datasets through very large data pooling efforts. This goal has considerable importance in light of growing concerns over the rigor and reproducibility of many neuroimaging and genomic findings. ENIGMA has had many successes (including a genome wide association study on cortical thickness with over 51,556 participants, Grasby et al., 2021 Science), and a number of working groups have been established which leverage the standardized multi-site ENIGMA preprocessing pipelines and analytic methods to focus on the neurobiology of specific diseases. This application’s PI co-created the ENIGMA Addiction working group which now has access to datasets representing over 24,000 participants contributed by 103 PI members from 71 different institutions in 16 countries spanning 6 continents. There have been 27 peer reviewed publications since the start of the initial R01 with another 8 papers currently under review. Building on our initial funding (R01 DA047119), we propose to further expand the Addiction working group to support the largest international resource of its kind for the scientific community. Dataset users are encouraged to propose and lead their own projects. Curation of the shared database by the ENIGMA Addiction team according to standardized protocols for harmonization and quality control is a cost-effective means of maximizing heavy investments in data collection and overcomes an insurmountable obstacle for younger investigators and investigators from low or middle income countries. ENIGMA Addiction has approved 43 projects, 16 of which are completed and 27 are ongoing, including a full 30 projects led by investigators from outside of the central research team at the University of Vermont. These projects investigate topics ranging from sex differences to early markers of addiction risk to machine learning classification. Research projects can be performed via guest access to a high performance supercomputer hosted at the University of Vermont or through COINSTAC, a federated cloud- based meta-analytic pipeline. Analyses have been completed on thousands of pooled participants with structural MRI, DTI, resting state fMRI or genetic data and we have now expanded to include task-based fMRI. During the next phase of funding, the team at UVM will engage in two main analytic efforts whose success is favored by the large database afforded by this working group, namely comprehensive interrogation of psychiatric comorbidity by joining efforts with other large ENIGMA working groups and, second, identification of biologically meaningful sub-groups within the population of problematic substance users with distinct etiology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	002	6	4/1/2025	COMPETING CONTINUATION	$21,316
2025	2022	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	001	4	4/1/2025	SUPPLEMENT FOR EXPANSION	-$1,701
2025	2022	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	5	4/1/2025	NON-COMPETING CONTINUATION	-$19,615
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $688,498 )
2024	2024	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	6	6/4/2024	COMPETING CONTINUATION	$688,498
														Subtotal = $688,498

Issue Date FY: 2022 ( Subtotal = $716,419 )
2022	2022	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	001	4	9/2/2022	SUPPLEMENT FOR EXPANSION	$57,155
2022	2022	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	5	8/17/2022	NON-COMPETING CONTINUATION	$659,264
														Subtotal = $716,419

Issue Date FY: 2021 ( Subtotal = $659,264 )
2021	2021	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	4	8/9/2021	NON-COMPETING CONTINUATION	$659,264
														Subtotal = $659,264

Issue Date FY: 2020 ( Subtotal = $659,264 )
2020	2020	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	3	6/29/2020	NON-COMPETING CONTINUATION	$659,264
														Subtotal = $659,264

Issue Date FY: 2019 ( Subtotal = $663,476 )
2019	2019	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	2	8/6/2019	NON-COMPETING CONTINUATION	$663,476
														Subtotal = $663,476

Issue Date FY: 2018 ( Subtotal = $669,057 )
2018	2018	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Drug Use and Addiction Research Programs	000	1	9/7/2018	NEW	$669,057
														Subtotal = $669,057

Grand Total All Awards = $4,055,978

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ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next Steps

Award Number: R01DA047119

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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