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Building on Needle Exchange to Optimize HIV Prevention/Treatment

Award Number: R01DA045556
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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View Award Description

Building on Needle Exchange to Optimize HIV Prevention/Treatment - PROJECT SUMMARY Latinos are among the most heavily impacted communities by the COVID-19 pandemic in the US, with more than 3 times higher rate than non-Hispanic whites. To address this disparity, this team of investigators and community partners has established a multi-pronged approach that leverages the skill set of trusted bilingual/bicultural peer navigators (or promotoras) to address social determinants of health (SDOH) that create barriers to testing (such as lack of insurance, immigration status, stigmatization or loss of job/income), and to expand access to free COVID-19 testing in community settings. Our preliminary findings show that leveraging the promotora model for timely delivery of results (within 48 hours), paired with rapid linkage of COVID-19 positive patients to critical services (including clinical follow-up, food delivery, cash assistance, and/or isolation hotel), and referral of contacts for testing, increased acceptability and uptake of COVID-19 testing in a heavily impacted Latino community. The overall goal of this Phase I Testing Research Project called Juntos (Together) is to work closely with our community partners to systematically evaluate and refine current COVID-19 testing strategies, and to implement and evaluate innovative customized strategies to rapidly increase reach, access, acceptance, uptake, and sustainment of FDA-authorized/approved diagnostics (especially viral tests) for this highly vulnerable and health care marginalized community. Leveraging community partnerships and prior experience implementing an HIV testing campaign, we will develop and evaluate a customized Juntos COVID- 19 testing campaign to address specific common concerns in the Latino community and link users to existing Johns Hopkins COVID-19 community testing sites and to new options, including home-based and/or self- testing kits and rapid tests (Aim 1). To assess the overall impact of the Juntos COVID-19 Testing Project, we will rely on the latest in causal inference methods for evaluating population-level health interventions and implement a synthetic control analysis to compare testing uptake and positivity rate among Latinos in Baltimore City (intervention site) as compared to control zip codes across Maryland. (Aim 2). Finally, informed by Consolidated Framework for Implementation Research (CFIR) and RE-AIM framework, we will assess the implementation determinants, mechanisms, and outcomes of existing and novel Juntos testing interventions to inform future broad-scale implementation (Aim 3). We have assembled a multi-disciplinary team with methodological expertise in implementation science, community-based research, and laboratory medicine, and have a mature and long-standing collaboration with our partners at Esperanza Center, Casa de Maryland, the Mayor's Office of Immigrant Affairs, and religious leaders. Our team is enthusiastic to propose this implementation study to enhance access to testing for the Latino community, and will actively coordinate and share data and protocols with other grantees, the CDCC, and other research supported by the RADx-UP program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$41,866 )
2025	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	5	8/29/2025	SUPPLEMENT FOR EXPANSION	-$38,560
2025	2021	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	5	1/3/2025	NON-COMPETING CONTINUATION	-$3,306
														Subtotal = -$41,866

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	5	3/29/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = -$144,039 )
2023	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	003	5	8/10/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	002	5	7/28/2023	NON-COMPETING CONTINUATION	$0
2023	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	4	1/11/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2020	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	4	7/27/2023	SUPPLEMENT FOR EXPANSION	-$144,039
														Subtotal = -$144,039

Issue Date FY: 2022 ( Subtotal = $509,046 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	5	5/2/2022	SUPPLEMENT FOR EXPANSION	$509,046
2022	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	4	4/25/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $509,046

Issue Date FY: 2021 ( Subtotal = $997,878 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	5	7/16/2021	NON-COMPETING CONTINUATION	$997,878
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	002	4	8/23/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	000	4	12/9/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $997,878

Issue Date FY: 2020 ( Subtotal = $2,569,080 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Research Support	001	4	9/24/2020	SUPPLEMENT FOR EXPANSION	$1,570,444
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	4	7/17/2020	NON-COMPETING CONTINUATION	$998,636
														Subtotal = $2,569,080

Issue Date FY: 2019 ( Subtotal = $886,061 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	3	7/30/2019	NON-COMPETING CONTINUATION	$886,061
														Subtotal = $886,061

Issue Date FY: 2018 ( Subtotal = $880,508 )
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	2	7/13/2018	NON-COMPETING CONTINUATION	$880,508
														Subtotal = $880,508

Issue Date FY: 2017 ( Subtotal = $955,194 )
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	1	9/8/2017	NEW	$955,194
														Subtotal = $955,194

Grand Total All Awards = $6,611,862

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Building on Needle Exchange to Optimize HIV Prevention/Treatment

Award Number: R01DA045556

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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