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The Influence of Gonadal Hormones on Opioid Use

Award Number: R01DA045364
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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The Influence of Gonadal Hormones on Opioid Use - PROJECT SUMMARY Preclinical, clinical, and epidemiological studies have consistently revealed sex- and gender-related differences in substance use and the development of substance use disorders. Many of these sex differences can be attributed to gonadal hormones, and the effects of ovarian hormones across the estrous/menstrual cycle have been well documented for cocaine, methamphetamine, and other stimulants. Far fewer studies have examined the role of androgen hormones on drug sensitivity, and relatively few studies have examined the role of ovarian hormones on the self-administration of heroin and other opioids. This represents a limitation of the existing literature, given evidence that gonadal hormones alter sensitivity to the abuse-related effects of opioids in a manner very differently from the way they alter sensitivity to the effects of stimulants. The scientific objective of the proposed project is to characterize the effects of ovarian and androgen hormones on heroin self-administration in sexually mature male and female rats, while identifying hormonally based treatment interventions for opioid use disorders. To this end, Aim 1 will examine the effects of exogenous estradiol, progesterone, and their combination on heroin self-administration in gonadectomized male and female rats. Aim 2 will examine the role of endogenous ovarian hormones in the suppression of heroin self-administration during proestrus through receptor-selective antagonists. Aim 3 will examine the effects of exogenous estradiol and progesterone on heroin self-administration in gonadally intact female rats. Aim 4 will examine the effects of exogenous testosterone on heroin self-administration in gonadectomized male and female rats. Finally, Aim 5 will examine the effects of an androgen steroid inhibitor on heroin self-administration in gonadally intact male rats. The ultimate goal of these studies is to better predict sex-related differences in opioid use disorders and to identify novel and sex-specific treatment interventions for opioid abuse and addiction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	THE TRUSTEES OF DAVIDSON COLLEGE	209 RIDGE RD	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	5	12/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $327,025 )
2022	2022	TRUSTEES OF DAVIDSON COLLEGE, THE	209 RIDGE RD	DAVIDSON	NC	28035	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	5	7/22/2022	NON-COMPETING CONTINUATION	$327,025
														Subtotal = $327,025

Issue Date FY: 2021 ( Subtotal = $324,418 )
2021	2021	TRUSTEES OF DAVIDSON COLLEGE, THE	209 RIDGE RD	DAVIDSON	NC	28035	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	4	7/21/2021	NON-COMPETING CONTINUATION	$324,418
														Subtotal = $324,418

Issue Date FY: 2020 ( Subtotal = $321,886 )
2020	2020	TRUSTEES OF DAVIDSON COLLEGE, THE	209 RIDGE RD	DAVIDSON	NC	28035	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	3	7/27/2020	NON-COMPETING CONTINUATION	$321,886
														Subtotal = $321,886

Issue Date FY: 2019 ( Subtotal = $319,428 )
2019	2019	TRUSTEES OF DAVIDSON COLLEGE, THE	209 RIDGE RD	DAVIDSON	NC	28035	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	2	7/25/2019	NON-COMPETING CONTINUATION	$319,428
														Subtotal = $319,428

Issue Date FY: 2018 ( Subtotal = $317,042 )
2018	2018	TRUSTEES OF DAVIDSON COLLEGE, THE	209 RIDGE RD	DAVIDSON	NC	28035	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	1	9/18/2018	NEW	$317,042
														Subtotal = $317,042

Grand Total All Awards = $1,609,799

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The Influence of Gonadal Hormones on Opioid Use

Award Number: R01DA045364

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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