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Using existing data to understand and ameliorate risk in opioid agonist therapy

Award Number: R01DA044170
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Using existing data to understand and ameliorate risk in opioid agonist therapy - PROJECT SUMMARY/ABSTRACT The United States is in the midst of an opioid epidemic, leading to unprecedented levels of overdose deaths and other harms. Effective treatment for opioid use disorders is available, in the form of opioid agonist therapy (OAT) with methadone or buprenorphine. However, there are significant questions about the risk of adverse clinical outcomes, including mortality and hospitalization during and after treatment, and unplanned treatment cessation. What is the magnitude of these risks, and what patient, treatment setting, and provider factors may contribute to or protect against risk? Additionally, it is increasingly clear that more sophisticated approaches to patient assessment and treatment planning than are currently used are needed to minimise risk. We aim to: 1. Determine the magnitude of risk for specific adverse clinical outcomes (e.g. mortality, hospitalization and ED presentation, and unplanned treatment cessation) during and after OAT with methadone and buprenorphine; 2. Identify patient, treatment setting, and provider risk factors associated with adverse clinical outcomes during and after OAT with methadone and buprenorphine; and 3. Develop a risk prediction model to identify patients at greatest risk of adverse clinical outcomes during and after OAT. To achieve these aims, this project will use existing population-based Australian data on OAT, linked to several health and criminal justice datasets to provide a rich understanding of treatment exposures and outcomes. These data will be used to inform strategies to guide the delivery of high-quality treatment for opioid use disorder in the United States. Specifically, the project will provide data about the magnitude of risk of adverse clinical outcomes during specific treatment and post-treatment periods, and identify patient, treatment setting and provider factors that influence risk. Additionally, it will use innovative machine learning techniques to demonstrate the potential for routinely collected data to be used to assess patient risk at point-of-care, allowing for the development of tailored treatment plans that minimize risk and maximize treatment retention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$41,072 )
2025	2019	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON				AUS	Drug Use and Addiction Research Programs	000	3	10/1/2024	SUPPLEMENT FOR EXPANSION	-$41,072
														Subtotal = -$41,072

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON				AUS	Drug Use and Addiction Research Programs	000	3	4/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $246,217 )
2019	2019	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	002	3	9/13/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	000	3	8/27/2019	NON-COMPETING CONTINUATION	$197,617
2019	2019	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	001	3	8/29/2019	SUPPLEMENT FOR EXPANSION	$48,600
														Subtotal = $246,217

Issue Date FY: 2018 ( Subtotal = $178,129 )
2018	2018	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	002	2	7/23/2018	NON-COMPETING CONTINUATION	$197,617
2018	2017	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	000	1	11/24/2017	NEW	-$10,644
2018	2017	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	001	1	1/5/2018	NEW	-$8,844
														Subtotal = $178,129

Issue Date FY: 2017 ( Subtotal = $216,702 )
2017	2017	UNIVERSITY OF NEW SOUTH WALES	HIGH ST	KENSINGTON	NSW	2052		AUS	Drug Use and Addiction Research Programs	000	1	9/13/2017	NEW	$216,702
														Subtotal = $216,702

Grand Total All Awards = $599,976

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Using existing data to understand and ameliorate risk in opioid agonist therapy

Award Number: R01DA044170

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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