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Experimental Mediation Research Aimed at Enhancing Adolescent Substance Abuse Treatment

Award Number: R01DA043578
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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Experimental Mediation Research Aimed at Enhancing Adolescent Substance Abuse Treatment - PROJECT SUMMARY/ABSTRACT Adolescents with substance use disorders (SUD) are at high risk for significant deleterious outcomes. Although several evidence-based practices for adolescent SUD exist, they yield only small to medium effects that rapidly diminish (30-70% 6-month relapse rates). A promising approach for determining how to enhance treatment is experimental mediation research. In contrast to traditional correlational mediation approaches, experimental mediation permits causal inference and is comprised of key steps: (A) Identify the putative mediating variable for a treatment. (B) Enhance the treatment to target that mediator more intensely. (C) Randomize youth to conditions, with the standard and enhanced versions of the treatment targeting different “levels” of the same mediator. (D) Measure the mediator and outcomes longitudinally. (E) Perform modern mediation analyses, coupled with analyses evaluating causal inference, to determine if changes in the mediator are responsible for changes in outcomes. This experimental test of mediation, focused on causality, facilitates rapid improvement of treatments by specifying change mechanisms to target in order to improve outcomes. These steps will be followed to elucidate the mediating processes in treatment for adolescent SUD, with the ultimate goal of enhancing the strength and durability of SUD treatments. The three most common putative mediating variables in adolescent SUD treatments are parent management, behavioral regulation, and peer relations. For this study, parent management was chosen as the target because it has evidenced the most potential for yielding generalizable change in youth outcomes and also has been shown to indirectly improve youths’ behavioral regulation and peer relations. Of existing treatments for adolescent SUD, family-based Contingency Management (CM) was chosen as the treatment to enhance because it is highly amenable to an augmented focus on parenting, is less complex relative to other SUD treatments, and has amassed considerable support in terms of efficacy and dissemination potential. Thus, following experimental mediation steps, youth with SUD will be randomized to receive either standard CM or enhanced CM (i.e., CM+) that targets parenting more intensely. Repeated assessments for 12 months and longitudinal analyses will allow testing of mediating processes. We will examine whether parent management skills mediate the effect of treatment on youth substance use and behavior problems (Aim 1). In addition, we will determine whether parent management skills mediate the effect of treatment on youth behavioral regulation and deviant peer relations (Aim 2). Finally, we will test whether behavioral regulation and deviant peer relations mediate the effect of parent management on youth substance use and behavior problems (Aim 3). Findings could have broad impact across multiple adolescent SUD treatments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	OREGON SOCIAL LEARNING CENTER, INC	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	5	12/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	5	6/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $700,810 )
2021	2021	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	5	7/23/2021	NON-COMPETING CONTINUATION	$700,810
														Subtotal = $700,810

Issue Date FY: 2020 ( Subtotal = $671,383 )
2020	2020	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	4	6/19/2020	NON-COMPETING CONTINUATION	$671,383
														Subtotal = $671,383

Issue Date FY: 2019 ( Subtotal = $663,352 )
2019	2019	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	3	7/17/2019	NON-COMPETING CONTINUATION	$663,352
														Subtotal = $663,352

Issue Date FY: 2018 ( Subtotal = $662,008 )
2018	2018	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	2	7/11/2018	NON-COMPETING CONTINUATION	$662,008
														Subtotal = $662,008

Issue Date FY: 2017 ( Subtotal = $678,949 )
2017	2017	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	1	8/17/2017	NEW	$678,949
														Subtotal = $678,949

Grand Total All Awards = $3,376,502

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Experimental Mediation Research Aimed at Enhancing Adolescent Substance Abuse Treatment

Award Number: R01DA043578

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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