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Endocannabinoid Biosynthesis in Inflammation and Pain

Award Number: R01DA043571
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2029

Group Awards By:

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Endocannabinoid Biosynthesis in Inflammation and Pain - Project Summary In the initial 5 years of this grant, our group has advanced the field of endocannabinoid therapeutics by discovering novel metabolic and signaling functions for the endocannabinoid biosynthetic enzyme DAGLβ in inflammation and pain response. We developed drug delivery strategies for localizing DAGLβ inhibitors to inflammatory sites for potent pain alleviation in preclinical models. We developed phosphoproteomic, chemoproteomic, and lipidomic capabilities to enable biomarker and drug discovery in pain. This renewal application will extend our preclinical investigations of DAGLβ inhibitors as non-opioid analgesics to include kinase activation as a testable mechanism. We will build on the key biological discoveries, productivity, and technological investment of the first funding period to address key gaps in knowledge to probe how disruption of DAGLβ lipid metabolism activates kinase signal transduction, test whether augmented kinase activation can be achieved using new liposomal formulations of DAGLβ inhibitors and uncover the druggable phosphoproteome in inflammatory and neuropathic pain states. We plan to test our central hypothesis that DAGLβ signals through bioenergetic pathways to alter the macrophage phosphoproteome in local inflammatory responses in pain. An improved understanding of endocannabinoid biosynthetic mechanisms in chronic pain states is important for guiding development of non-addictive, targeted analgesics to address the opioid epidemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $503,536 )
2026	2026	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Drug Use and Addiction Research Programs	001	9	2/6/2026	NON-COMPETING CONTINUATION	$50,353
2026	2026	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Drug Use and Addiction Research Programs	000	9	1/30/2026	NON-COMPETING CONTINUATION	$453,183
														Subtotal = $503,536

Issue Date FY: 2025 ( Subtotal = $501,620 )
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Drug Use and Addiction Research Programs	001	8	2/25/2025	NON-COMPETING CONTINUATION	$451,458
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Drug Use and Addiction Research Programs	002	8	4/10/2025	NON-COMPETING CONTINUATION	$50,162
2025	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	5	1/29/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $501,620

Issue Date FY: 2024 ( Subtotal = $43,244 )
2024	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Drug Use and Addiction Research Programs	001	7	2/12/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$489,836
2024	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Drug Use and Addiction Research Programs	002	7	2/27/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$43,244
2024	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	6	2/12/2024	COMPETING CONTINUATION	-$489,836
														Subtotal = $43,244

Issue Date FY: 2023 ( Subtotal = $489,836 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	6	8/30/2023	COMPETING CONTINUATION	$489,836
														Subtotal = $489,836

Issue Date FY: 2022 ( Subtotal = -$19,866 )
2022	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	4	11/26/2021	SUPPLEMENT FOR EXPANSION	-$19,866
														Subtotal = -$19,866

Issue Date FY: 2021 ( Subtotal = $397,603 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	003	5	7/22/2021	NON-COMPETING CONTINUATION	-$62,662
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	4	5/24/2021	SUPPLEMENT FOR EXPANSION	$9,863
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	002	5	6/15/2021	NON-COMPETING CONTINUATION	$450,402
2021	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	001	4	5/26/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $397,603

Issue Date FY: 2020 ( Subtotal = $451,488 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	4	6/19/2020	NON-COMPETING CONTINUATION	$388,826
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	001	4	6/22/2020	SUPPLEMENT FOR EXPANSION	$62,662
														Subtotal = $451,488

Issue Date FY: 2019 ( Subtotal = $392,503 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	3	6/12/2019	NON-COMPETING CONTINUATION	$392,503
														Subtotal = $392,503

Issue Date FY: 2018 ( Subtotal = $392,503 )
2018	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	2	6/27/2018	NON-COMPETING CONTINUATION	$392,503
														Subtotal = $392,503

Issue Date FY: 2017 ( Subtotal = $391,367 )
2017	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Drug Use and Addiction Research Programs	000	1	9/5/2017	NEW	$391,367
														Subtotal = $391,367

Grand Total All Awards = $3,543,834

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Endocannabinoid Biosynthesis in Inflammation and Pain

Award Number: R01DA043571

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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