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COINSTAC 2.0: decentralized, scalable analysis of loosely coupled data

Award Number: R01DA040487
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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COINSTAC 2.0: decentralized, scalable analysis of loosely coupled data - Project Summary/Abstract The brain imaging community is greatly benefiting from extensive data sharing efforts currently underway. However, there is still a major gap in that much data is still not openly shareable, which we propose to address. In addition, current approaches to data sharing often include significant logistical hurdles both for the investigator sharing the data (e.g. often times multiple data sharing agreements and approvals are required from US and international institutions) as well as for the individual requesting the data (e.g. substantial computational re- sources and time is needed to pool data from large studies with local study data). This needs to change, so that the scientific community can create a venue where data can be collected, managed, widely shared and analyzed while also opening up access to the (many) data sets which are not currently available (see overview on this from our group7). The large amount of existing data requires an approach that can analyze data in a distributed way while (if required) leaving control of the source data with the individual investigator or the data host; this motivates a dynamic, decentralized way of approaching large scale analyses. During the previous funding period, we developed a peer-to-peer system called the Collaborative Informatics and Neuroimaging Suite Toolkit for Anonymous Computation (COINSTAC). Our system provides an independent, open, no-strings-attached tool that performs analysis on datasets distributed across different locations. Thus, the step of actually aggregating data is avoided, while the strength of large-scale analyses can be retained. During this new phase we respond to the need for advanced algorithms such as linear mixed effects models and deep learning, by proposing to develop decentralized models for these approaches and also implement a fully scalable cloud-based framework with enhanced security features. To achieve this, in Aim 1, we will incorporate the necessary functionality to scale up analyses via the ability to work with either local or commercial private cloud environments, together with advanced visualization, quality control, and privacy and security features. This suite of new functions will open the floodgates for the use of COINSTAC by the larger neuroscience community to enable new discovery and analysis of unprecedented amounts of brain imaging data located throughout the world. We will also improve usability, training materials, engage the community in contributing to the open source code base, and ultimately facilitate the use of COINSTAC's tools for additional science and discovery in a broad range of applications. In Aim 2 we will extend the framework to handle powerful algorithms such as linear mixed effects models and deep learning, and to perform meta-learning for leveraging and updating fit models. And finally, in Aim 3, we will test this new functionality through a partnership with the worldwide ENIGMA addiction group, which is currently not able to perform advanced machine learning analyses on data that cannot be centrally located. We will evaluate the impact of 6 main classes of substances of abuse (e.g. methamphetamines, cocaine, cannabis, nicotine, opiates, alcohol and their combinations) using the new developed functionality. 3


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $613,218 )
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	10	6/18/2024	NON-COMPETING CONTINUATION	$613,218
														Subtotal = $613,218

Issue Date FY: 2023 ( Subtotal = $607,861 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	001	9	6/29/2023	NON-COMPETING CONTINUATION	$618,396
2023	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	4	3/13/2023	NON-COMPETING CONTINUATION	-$10,535
														Subtotal = $607,861

Issue Date FY: 2022 ( Subtotal = $1,007,178 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	003	8	7/15/2022	SUPPLEMENT FOR EXPANSION	$378,525
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	002	8	6/15/2022	NON-COMPETING CONTINUATION	$628,653
2022	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	001	6	11/24/2021	COMPETING CONTINUATION	$387,270
2022	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	5	11/24/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$387,270
														Subtotal = $1,007,178

Issue Date FY: 2021 ( Subtotal = $617,911 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	000	7	7/2/2021	NON-COMPETING CONTINUATION	$617,911
2021	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	001	5	9/14/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $617,911

Issue Date FY: 2020 ( Subtotal = $627,034 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	006	6	9/24/2020	COMPETING CONTINUATION	$627,034
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	005	5	9/24/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	002	5	12/27/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$399,268
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	004	5	1/10/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	001	4	12/27/2019	SUPPLEMENT FOR EXPANSION	-$282,320
2020	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	4	12/27/2019	NON-COMPETING CONTINUATION	-$116,948
2020	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	003	4	1/10/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $627,034

Issue Date FY: 2019 ( Subtotal = $585,151 )
2019	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Use and Addiction Research Programs	001	5	8/12/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$585,151
2019	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	4	8/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $585,151

Issue Date FY: 2018 ( Subtotal = $931,418 )
2018	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	001	4	9/4/2018	SUPPLEMENT FOR EXPANSION	$282,320
2018	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	4	4/20/2018	NON-COMPETING CONTINUATION	$649,098
														Subtotal = $931,418

Issue Date FY: 2017 ( Subtotal = $655,080 )
2017	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	3	4/17/2017	NON-COMPETING CONTINUATION	$589,571
2017	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Drug Use and Addiction Research Programs	001	3	5/22/2017	NON-COMPETING CONTINUATION	$65,509
														Subtotal = $655,080

Issue Date FY: 2016 ( Subtotal = $680,020 )
2016	2016	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	2	5/2/2016	NON-COMPETING CONTINUATION	$680,020
														Subtotal = $680,020

Issue Date FY: 2015 ( Subtotal = $727,692 )
2015	2015	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Drug Use and Addiction Research Programs	000	1	6/29/2015	NEW	$727,692
														Subtotal = $727,692

Grand Total All Awards = $7,052,563

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COINSTAC 2.0: decentralized, scalable analysis of loosely coupled data

Award Number: R01DA040487

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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