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Optimizing Text Messaging to Improve Adherence to Web-Based Cessation Treatment

Award Number: R01DA038139
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2015
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Optimizing Text Messaging to Improve Adherence to Web-Based Cessation Treatment - ¿ DESCRIPTION (provided by applicant): Reducing population smoking prevalence is an urgent public health priority that can save more lives and money than almost any other preventive intervention. The Internet offers a promising delivery channel for evidence-based cessation treatment and the potential for enormous public health impact (reach x efficacy). Millions of smokers use the Internet for cessation assistance each year. Studies have shown quit rates of 7-28% across various Internet programs, and a positive relationship between intensity of use and higher abstinence rates. However, most smokers engage minimally with even the best designed cessation websites, diminishing their impact due to limited use of effective treatment components. Poor adherence has been noted across Internet behavior change programs. The ubiquity of mobile devices and their effectiveness in promoting adherence in other areas of health behavior change make them a promising tool to address adherence in web-based interventions. Text messaging is accessible and easy to use; messages can proactively prompt/remind and encourage continued exploration of a web-based intervention; interactive text messaging can facilitate engagement with core Internet intervention components. We have identified 4 aspects of a text message intervention that may enhance its effectiveness in promoting adherence to a web-based cessation program: personalization (yes/no), integration (yes/no), dynamic tailoring (yes/no), and message intensity (standard/decreasing). Phase I of this two-phase study will use a 2-level full factorial design to test the impact of these 4 experimental features on adherence to a web-based intervention. The primary outcome in Phase I will be a composite metric of adherence that incorporates number of logins, time on site, page views, and use of interactive site components shown to predict abstinence. Participants will be N=860 adult smokers that are new registered users of an established Internet cessation program and enroll in its text message program. Based on Phase I, we will optimize our text message intervention to incorporate all experimental features shown to positively impact adherence. Phase II will be a 2-arm randomized trial to compare the efficacy of a web-based cessation program (WEB) alone and in conjunction with the optimal-adherence text messaging intervention (WEB+OA_TXT) on 30-day point prevalence abstinence at 9 months. Phase II participants will be N=600 adult smokers that are new registered users of an established Internet cessation program and enroll in text messaging. We will examine whether 3 month measures of adherence mediate treatment effects on outcome. Improving adherence to proven web-based cessation interventions is critical to leverage the potential public health impact of this "broad reach" treatment modality. The proposed study is innovative in its use of an optimized text messaging intervention to improve adherence. Study findings will inform adherence research in other areas and will add to the growing knowledge base about the overall effectiveness of Internet cessation programs and mechanisms through which their population impact on smoking prevalence can be improved.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$32,968 )
2022	2019	TRUTH INITIATIVE FOUNDATION	900 G ST NW FOURTH FL	WASHINGTON	DC	20001	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	000	5	2/16/2022	NON-COMPETING CONTINUATION	-$32,968
														Subtotal = -$32,968

Issue Date FY: 2019 ( Subtotal = $537,487 )
2019	2019	TRUTH INITIATIVE FOUNDATION	900 G ST NW FOURTH FL	WASHINGTON	DC	20001	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	000	5	7/23/2019	NON-COMPETING CONTINUATION	$537,487
														Subtotal = $537,487

Issue Date FY: 2018 ( Subtotal = $546,189 )
2018	2018	TRUTH INITIATIVE FOUNDATION	900 G ST NW FOURTH FL	WASHINGTON	DC	20001	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	000	4	7/25/2018	NON-COMPETING CONTINUATION	$546,189
														Subtotal = $546,189

Issue Date FY: 2017 ( Subtotal = $579,315 )
2017	2017	TRUTH INITIATIVE FOUNDATION	900 G ST NW FOURTH FL	WASHINGTON	DC	20001	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	000	3	7/14/2017	NON-COMPETING CONTINUATION	$579,315
														Subtotal = $579,315

Issue Date FY: 2016 ( Subtotal = $544,536 )
2016	2016	American Legacy Foundation	1724 Massachussets Ave NW	Washington	DC	20036	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	000	2	8/10/2016	NON-COMPETING CONTINUATION	$544,536
														Subtotal = $544,536

Issue Date FY: 2015 ( Subtotal = $603,096 )
2015	2015	American Legacy Foundation	1724 Massachussets Ave NW	Washington	DC	20036	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	000	1	8/21/2015	NEW	$735,072
2015	2015	American Legacy Foundation	1724 Massachussets Ave NW	Washington	DC	20036	DISTRICT OF COLUMBIA	USA	Drug Use and Addiction Research Programs	001	1	8/24/2015	NEW	-$131,976
														Subtotal = $603,096

Grand Total All Awards = $2,777,655

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Optimizing Text Messaging to Improve Adherence to Web-Based Cessation Treatment

Award Number: R01DA038139

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2015

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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