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Calcium-related neurotoxicity of cocaine

Award Number: R01DA029718
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Calcium-related neurotoxicity of cocaine - Disfunction of the prefrontal cortex (PFC), plays a crucial role in compulsive cocaine use and addiction. The role of glia in addition to that of neurons and vascular networks in cocaine-induced PFC dysfunction remains elusive. In the completing R01, we showed that the neurotoxic effects of cocaine were associated with persistent decreases in cerebral blood flow (CBF) and an elevation in intracellular calcium in cortex; however, we did not assess the role of glia versus that of neurons on the CBF decreases. This renewal application, Calcium-related neurotoxicity of cocaine , will assess the effects of acute and chronic cocaine on astrocytic Ca2+ and its role on the CBF deficits and neuronal Ca2+ increases in PFC and their association with cocaine intake in an animal model of compulsive-like cocaine self-administration. Specifically, we will apply multimodality optical imaging (MOI) in combination with genetically-encoded Ca2+ indicators to capture activities in neurons (jRGECO1a) and astrocytes (GCaMP6f) and ultrahigh- resolution optical coherence angiography and Doppler tomography (µODT) for quantitative imaging of 3D CBF networks in PFC of GFAP cre mice (Aim 1). We will apply chemogenetics with Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to manipulate astrocytic Ca2+ accumulation while assessing its consequences on acute and chronic cocaine’s vascular and neuronal effects and cocaine intake (Aim 2, Aim 3). These studies will be valuable for understanding how astrocyte and neuronal networks in the PFC interact and mediate the associated local neurovascular responses to cocaine and how they contribute to compulsive-like drug consumption, providing knowledge to guide development of novel addiction interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $438,344 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	10	4/10/2025	NON-COMPETING CONTINUATION	$43,834
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	10	2/26/2025	NON-COMPETING CONTINUATION	$394,510
														Subtotal = $438,344

Issue Date FY: 2024 ( Subtotal = $438,344 )
2024	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	9	1/25/2024	NON-COMPETING CONTINUATION	$394,510
2024	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	9	4/26/2024	NON-COMPETING CONTINUATION	$43,834
														Subtotal = $438,344

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	8	1/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $435,889 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	8	3/30/2022	NON-COMPETING CONTINUATION	$43,834
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	8	1/24/2022	NON-COMPETING CONTINUATION	$394,510
2022	2017	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	002	5	6/29/2022	NON-COMPETING CONTINUATION	-$2,455
2022	2017	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	003	5	6/29/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $435,889

Issue Date FY: 2021 ( Subtotal = $414,294 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	7	2/10/2021	NON-COMPETING CONTINUATION	$404,405
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	7	5/21/2021	SUPPLEMENT FOR EXPANSION	$9,889
														Subtotal = $414,294

Issue Date FY: 2020 ( Subtotal = $428,727 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	6	3/25/2020	COMPETING CONTINUATION	$428,727
														Subtotal = $428,727

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	5	2/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $408,122 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	002	5	5/11/2017	SUPPLEMENT FOR EXPANSION	$2,755
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	5	1/19/2017	NON-COMPETING CONTINUATION	$344,250
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	5	5/8/2017	SUPPLEMENT FOR EXPANSION	$22,866
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	003	5	5/22/2017	NON-COMPETING CONTINUATION	$38,251
														Subtotal = $408,122

Issue Date FY: 2016 ( Subtotal = $388,450 )
2016	2016	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	4	2/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$388,450
														Subtotal = $388,450

Issue Date FY: 2015 ( Subtotal = $13,783 )
2015	2015	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	3	4/29/2015	SUPPLEMENT FOR EXPANSION	$13,783
2015	2014	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	3	2/18/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $13,783

Issue Date FY: 2014 ( Subtotal = $419,992 )
2014	2014	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	3	2/28/2014	NON-COMPETING CONTINUATION	$41,168
2014	2014	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	002	3	5/13/2014	SUPPLEMENT FOR EXPANSION	$8,305
2014	2014	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	3	1/7/2014	NON-COMPETING CONTINUATION	$370,519
														Subtotal = $419,992

Issue Date FY: 2013 ( Subtotal = $423,565 )
2013	2013	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	2	5/3/2013	SUPPLEMENT FOR EXPANSION	$8,118
2013	2013	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	002	2	5/16/2013	NON-COMPETING CONTINUATION	$25,965
2013	2013	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	2	1/25/2013	NON-COMPETING CONTINUATION	$389,482
														Subtotal = $423,565

Issue Date FY: 2012 ( Subtotal = $399,698 )
2012	2012	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	1	5/23/2012	SUPPLEMENT FOR EXPANSION	$11,338
2012	2012	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	1	2/14/2012	NEW	$388,360
														Subtotal = $399,698

Grand Total All Awards = $4,209,208

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Calcium-related neurotoxicity of cocaine

Award Number: R01DA029718

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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