Monday, June 30, 2025 6/30/2025

Physical Activity and Substance Abuse

Award Number: R01DA027485
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2009
PERIOD OF PERFORMANCE END DATE: 08/31/2016

Group Awards By:

View Award Description

Physical Activity and Substance Abuse - DESCRIPTION (provided by applicant): Aerobic exercise produces a host of psychological effects that are negatively correlated with substance abuse and dependence. For instance, long-term voluntary exercise increases measures of self-esteem and well-being, and decreases measures of depression and anxiety. Moreover, epidemiological studies report that participation in activities that promote physical fitness is associated with a lower incidence of tobacco and substance use among adolescent populations. Despite these promising findings, remarkably few clinical and laboratory stories have specifically examined a potential causal relationship between aerobic exercise and a decreased propensity to engage in drug-seeking behavior. In the proposed series of studies, we will evaluate the efficacy of aerobic exercise to (1) attenuate the escalation of cocaine intake under extended-access conditions, (2) prevent the dysregulated patterns of drug intake that emerge during a prolonged binge, and (3) decrease cocaine-primed and cue-induced reinstatement following a period of abstinence. This project will be the first systematic examination of the effects of exercise on a range of behavioral processes that are believed to be involved in the etiology of addictive behavior. Furthermore, these studies will examine the effects of exercise in both male and female subjects, and determine whether there are sex differences in these effects. As part of its translational appeal, the project will examine exercise as both a preventative intervention (i.e., before drug use has been initiated) and as a treatment intervention (i.e., after self-administration has been firmly established). Collectively, these studies should significantly advance our knowledge on how physical activity interacts with the endogenous reward system to alter sensitivity to cocaine and provide critical guidance for the design and execution of future studies examining the effects of exercise in clinical populations. PUBLIC HEALTH RELEVANCE: Aerobic exercise has been recommended as a potential treatment for substance abuse, but very little research has been conducted on its ability to reduce drug self-administration. The purpose of this project is to examine the effectiveness of aerobic exercise to (1) reduce the escalation of cocaine intake under free-access conditions, (2) prevent the high rates of cocaine intake during a prolonged binge, and (3) decrease the reinstatement of drug-seeking behavior following exposure to cocaine or cocaine-related cues. This project will be the first systematic examination of the effects of exercise on a range of behavioral processes that are believed to be involved in the development of substance use disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$8 )
2017	2013	TRUSTEES OF DAVIDSON COLLEGE, THE	209 RIDGE RD	DAVIDSON	NC	28035	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	5	1/5/2017	NON-COMPETING CONTINUATION	-$8
														Subtotal = -$8

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	DAVIDSON COLLEGE	POST OFFICE BOX 1568	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	5	7/16/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $185,377 )
2013	2013	DAVIDSON COLLEGE	POST OFFICE BOX 1568	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	5	8/26/2013	NON-COMPETING CONTINUATION	$185,377
														Subtotal = $185,377

Issue Date FY: 2012 ( Subtotal = $190,926 )
2012	2012	DAVIDSON COLLEGE	POST OFFICE BOX 1568	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	4	8/20/2012	NON-COMPETING CONTINUATION	$190,926
														Subtotal = $190,926

Issue Date FY: 2011 ( Subtotal = $186,174 )
2011	2011	DAVIDSON COLLEGE	POST OFFICE BOX 1568	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	3	8/16/2011	NON-COMPETING CONTINUATION	$186,174
														Subtotal = $186,174

Issue Date FY: 2010 ( Subtotal = $190,017 )
2010	2010	DAVIDSON COLLEGE	POST OFFICE BOX 1568	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	2	8/18/2010	NON-COMPETING CONTINUATION	$190,017
														Subtotal = $190,017

Issue Date FY: 2009 ( Subtotal = $190,088 )
2009	2009	DAVIDSON COLLEGE	POST OFFICE BOX 1568	DAVIDSON	NC	28036	MECKLENBURG	USA	Drug Use and Addiction Research Programs	000	1	9/16/2009	NEW	$190,088
														Subtotal = $190,088

Grand Total All Awards = $942,574

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Physical Activity and Substance Abuse

Award Number: R01DA027485

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2009

PERIOD OF PERFORMANCE END DATE: 08/31/2016

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer