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Stage II Research on Outpatient Treatment for Adolescents with Comorbidity

Award Number: R01DA025616
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2016

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Stage II Research on Outpatient Treatment for Adolescents with Comorbidity - PROJECT SUMMARY/ABSTRACT Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth range from 25% up to 82%, and youths with a dual diagnosis are more than twice as costly to treat compared to those with no comorbidity. Community-based treatment for these youth most often is disjointed, with youth and families having to navigate separate treatment systems for the disorders or only receiving treatment for a single disorder. Notably, multiple studies have shown that youth with co-occurring problems have worse outcomes and return to pre-treatment levels of substance use more often and more rapidly than those without a psychiatric diagnosis. The applicant principal investigator, a new investigator, recently completed a NIDA-funded Stage I project focused on developing and piloting a psychosocial treatment specifically for youth presenting for outpatient treatment with co-occurring substance use and internalizing (i.e., mood and/or anxiety) problems. Results were promising with the experimental group exhibiting significantly less substance use and more rapid reductions in anxiety and depressive symptoms compared to the control group. In addition, extensive treatment and therapist training manuals were generated. The proposed research is a Stage II randomized clinical trial (RCT) to compare the experimental treatment (OutPatient Treatment for Adolescents; OPT-A) to an "active placebo" on key clinical indices from pre-treatment through 18 months. The proposed RCT (n = 160) employs the treatment manual, quality assurance protocol, and therapist training protocol developed and successfully piloted in the Stage I study, to evaluate the efficacy of OPT-A for youth referred to outpatient treatment of co- occurring substance use and internalizing problems. The following outcomes will be evaluated: drug use; mental health; behavioral, school, peer, and family functioning; and consumer satisfaction. In addition to providing a strong test of treatment efficacy, the proposed project will leverage the data collection of the RCT to provide a preliminary evaluation of putative mechanisms of action. In summary, this study will advance a promising treatment developed through the Stage I behavioral therapies development program to a Stage II controlled trial. It builds on the treatment manual, therapist training materials, and quality assurance system already developed. The intervention addresses one of the more prevalent and most challenging, costly, and understudied presenting problems among adolescent outpatients. If successful, this research could provide a considerable contribution in the treatment field for youth with co-occurring substance use and internalizing disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2013	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	6	9/30/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = -$498 )
2017	2013	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	6	11/2/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$498
														Subtotal = -$498

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	6	6/19/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2013	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	5	6/25/2014	NON-COMPETING CONTINUATION	-$536,750
2014	2013	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	6	6/26/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$536,750
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $593,121 )
2013	2013	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	5	6/27/2013	NON-COMPETING CONTINUATION	$593,121
														Subtotal = $593,121

Issue Date FY: 2012 ( Subtotal = $682,209 )
2012	2012	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	001	4	7/5/2012	SUPPLEMENT FOR EXPANSION	$70,800
2012	2012	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	4	6/19/2012	NON-COMPETING CONTINUATION	$611,409
														Subtotal = $682,209

Issue Date FY: 2011 ( Subtotal = $610,230 )
2011	2011	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	3	6/15/2011	NON-COMPETING CONTINUATION	$610,230
														Subtotal = $610,230

Issue Date FY: 2010 ( Subtotal = $632,963 )
2010	2010	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	2	6/2/2010	NON-COMPETING CONTINUATION	$632,963
														Subtotal = $632,963

Issue Date FY: 2009 ( Subtotal = $656,392 )
2009	2009	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	1	7/1/2009	NEW	$656,392
														Subtotal = $656,392

Grand Total All Awards = $3,174,417

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Stage II Research on Outpatient Treatment for Adolescents with Comorbidity

Award Number: R01DA025616

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2016

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