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HIV INFECTION IN ETHNIC MINORITY IDUS: AN INTERNATIONAL SYSTEMATIC REVIEW

Award Number: R01DA024612
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2008
PERIOD OF PERFORMANCE END DATE: 07/31/2014

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HIV INFECTION IN ETHNIC MINORITY IDUS: AN INTERNATIONAL SYSTEMATIC REVIEW - DESCRIPTION (provided by applicant): Racial/ethnic group disparities in HIV/AIDS are a critical public health issue in the US. These disparities are particularly dramatic with respect to injecting drug use. African-Americans constitute 13% of the US population and 52% of recent US injecting drug use AIDS cases; Hispanics constitute 14% of the US population and 24% of the injecting drug use AIDS cases. These disparities are not the result of more injecting drug users among African-Americans and Hispanics, but of higher rates of HIV infection among African- American and Hispanic IDUs in many areas of the country. Similar disparities-higher rates of HIV infection among ethnic minority IDUs-have also been observed in many foreign countries. Indeed the situation of ethnic minority IDUs in some developing countries can be considered a crisis, with extremely high incidence, prevalence and HIV-related mortality. Disparities have also been observed among non-injecting drug users, with ethnic minority group members having higher rates of HIV infection. The logical next step for addressing these disparities and this epidemiological conundrum is not another individual study, but a systematic review of the large number of relevant studies that have been conducted to date. Our proposed systematic review will use state-of-the-art methods and include the US and the international data on ethnic group differences in HIV infection among drug users. The specific aims include: Developing procedures for combining qualitative and quantitative data from multiple research studies of IDUs in a single geographic area into a "history of the HIV epidemic among IDUs" in that area. Determining the frequency of HIV epidemics in which substantial differences in HIV infection have and have not arisen in ethnic minority IDUs vs. ethnic majority IDUs in the US and internationally. Identifying potential causal factors that may generate substantial differences in HIV prevalence among racial/ethnic minority vs. ethnic majority IDUs. Identifying potential causal factors that may perpetuate or reduce differences in HIV infection among racial/ethnic differences over time. Identifying epidemiologic situations in which differences in HIV risk behaviors do or do not statistically "explain" differences in HIV infection among racial/ethnic groups of IDUs. The research will also create an extremely rich dataset on HIV infection among ethnic drug uses that will be made available for use by other researchers and HIV prevention service providers. The research addresses one of the most important aspects of HIV/AIDS-the frequent large disparities in HIV infection among ethnic groups in the US and in many other countries. The research will be an innovative application of state of the art methods for systematic review, including extensive searching for published and unpublished studies, quantitative coding of research reports, and applying meta-regression/hierarchical modeling to these problems. PUBLIC HEALTH RELEVANCE: Higher rates of HIV infection among African-American and Hispanic IDUs are a major health disparity in the US. African-Americans comprise 13% of the US population and 52% of injection drug use AIDS cases, Hispanics 14% of the populations and 24% of cases. Similar disparities, higher rates of HIV infection among ethnic minority IDUs, have also been observed in many foreign countries. An international systematic review and meta-analysis should greatly advance our understanding of these disparities and suggest how they might be ameliorated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2011	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	4	9/10/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $381,562 )
2011	2011	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	4	7/13/2011	NON-COMPETING CONTINUATION	$381,562
														Subtotal = $381,562

Issue Date FY: 2010 ( Subtotal = $549,319 )
2010	2010	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK	NY	10003	NEW YORK	USA	Drug Use and Addiction Research Programs	000	3	6/28/2010	NON-COMPETING CONTINUATION	$549,319
														Subtotal = $549,319

Issue Date FY: 2009 ( Subtotal = $545,434 )
2009	2009	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK	NY	10003	NEW YORK	USA	Drug Use and Addiction Research Programs	000	2	7/23/2009	NON-COMPETING CONTINUATION	$545,434
														Subtotal = $545,434

Issue Date FY: 2008 ( Subtotal = $571,320 )
2008	2008	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	1	7/3/2008	NEW	$571,320
														Subtotal = $571,320

Grand Total All Awards = $2,047,635

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HIV INFECTION IN ETHNIC MINORITY IDUS: AN INTERNATIONAL SYSTEMATIC REVIEW

Award Number: R01DA024612

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2008

PERIOD OF PERFORMANCE END DATE: 07/31/2014

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