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Intergenerational Studies Consortium: Understanding Mechanisms of Family Substance Use Transmission and Effects of Marijuana Legalization

Award Number: R01DA015485
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/20/2003
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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Intergenerational Studies Consortium: Understanding Mechanisms of Family Substance Use Transmission and Effects of Marijuana Legalization - Project Summary We propose to study intergenerational transmission of alcohol, tobacco, and other drug (ATOD) use, including marijuana use, across 3 generations (G1, G2, and G3), and effects of state recreational marijuana legalization (RML) on adolescents’ use. We will use a strategy of (1) intensive study of the long-term prospective Three Generational Study (3GS), a community sample consisting of up to two of the biological children (G3) of at-risk adult men (G2) in the Oregon Youth Study (OYS); (2) replications across three studies via collaborations with two other research teams, using data from the Seattle Social Development and Intergenerational Projects (SSDP/TIP) and the Rochester Youth Development and Intergenerational Studies (RYDS/RIGS); and (3) integrative data analysis (IDA) across these 3 studies on up to 1,200 G3 children of diverse socioeconomic, regional, and racial/ethnic backgrounds to answer high-impact questions including on state RML and use of lower prevalence drugs. For OYS/3GS, G1 parents and G2 men (currently ages 41–44 years) were involved since G2 were ages 9-10. The OYS men show high levels of substance use (est. 50% lifetime diagnoses for alcohol dependence or abuse and 50% prevalence of marijuana use in the mid 20s). G2 men, their G3 offspring, and G2 mothers were recruited to 3GS and followed from G3’s early childhood to (for earliest born G3) late adolescence. Specific Aims will be addressed through the collection and analysis of data that will expand the G3 sample size through adolescence in order to examine heterogeneity in growth of ATOD. Multiple indicators of ATOD in G2 and G3 have been and will be assessed to address intergenerational (IG) hypotheses related to IG congruence (similarities across generations in developmental patterns of ATOD use including onset, growth, and influences) versus discontinuity, and to heterogeneity in trajectories of use across adolescence. A dynamic developmental systems approach focusing on both general (e.g., externalizing) and substance-specific (e.g., parent marijuana use) risk factors will be used to trace developmental pathways to precursors (e.g., ATOD awareness), emergent behaviors (experimentation and onset), and regular and escalating ATOD use among individuals followed from early childhood to late adolescence. IG congruence versus discontinuity will be examined in relation to the transmission of contextual risk and problematic behaviors across three generations, and parenting behaviors and peer influences across two generations. Mediators and moderators of IG congruence will be examined, including parent and child gender and factors leading to IG amelioration versus worsening of ATOD use. Regarding RML, within- (pre- to post-RML) and between-child (living in/outside an RML state) effects on marijuana and other ATOD use will be examined, along with moderation of such effects by parent substance use history. The proposed study leverages 3 decades of NIH investment in IG studies to understand and disrupt the familial transmission of ATOD use problems, and quantify the public health impacts of state RML on adolescents from diverse backgrounds.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OREGON SOCIAL LEARNING CENTER, INC	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	20	9/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $617,946 )
2022	2022	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	20	6/1/2022	NON-COMPETING CONTINUATION	$617,946
														Subtotal = $617,946

Issue Date FY: 2021 ( Subtotal = $617,320 )
2021	2021	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	19	5/25/2021	NON-COMPETING CONTINUATION	$617,320
														Subtotal = $617,320

Issue Date FY: 2020 ( Subtotal = $616,441 )
2020	2020	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	18	5/14/2020	NON-COMPETING CONTINUATION	$616,441
														Subtotal = $616,441

Issue Date FY: 2019 ( Subtotal = $627,853 )
2019	2019	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	002	17	5/22/2019	NON-COMPETING CONTINUATION	$627,854
2019	2018	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	16	5/20/2019	COMPETING CONTINUATION	$115
2019	2017	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	15	5/20/2019	NON-COMPETING CONTINUATION	-$115
2019	2015	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	003	13	6/24/2019	NON-COMPETING CONTINUATION	-$1
														Subtotal = $627,853

Issue Date FY: 2018 ( Subtotal = $637,750 )
2018	2018	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	16	7/23/2018	COMPETING CONTINUATION	$637,750
2018	2017	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	15	7/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $637,750

Issue Date FY: 2017 ( Subtotal = $628,874 )
2017	2017	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	15	5/22/2017	NON-COMPETING CONTINUATION	$62,888
2017	2017	OREGON SOCIAL LEARNING CENTER	10 SHELTON MCMURPHEY BLVD	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	15	2/24/2017	NON-COMPETING CONTINUATION	$565,986
														Subtotal = $628,874

Issue Date FY: 2016 ( Subtotal = $721,898 )
2016	2016	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	14	5/5/2016	SUPPLEMENT FOR EXPANSION	$99,974
2016	2016	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	14	2/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$621,924
														Subtotal = $721,898

Issue Date FY: 2015 ( Subtotal = $619,140 )
2015	2015	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	13	2/19/2015	NON-COMPETING CONTINUATION	$619,140
														Subtotal = $619,140

Issue Date FY: 2014 ( Subtotal = $628,763 )
2014	2014	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	12	2/18/2014	NON-COMPETING CONTINUATION	$628,763
														Subtotal = $628,763

Issue Date FY: 2013 ( Subtotal = $628,523 )
2013	2013	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	11	5/7/2013	COMPETING CONTINUATION	$628,523
2013	2012	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	10	5/7/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $628,523

Issue Date FY: 2012 ( Subtotal = $1,029,574 )
2012	2012	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	10	3/16/2012	NON-COMPETING CONTINUATION	$1,029,574
														Subtotal = $1,029,574

Issue Date FY: 2011 ( Subtotal = $1,043,317 )
2011	2011	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	9	3/21/2011	NON-COMPETING CONTINUATION	$968,026
2011	2011	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	001	9	5/27/2011	NON-COMPETING CONTINUATION	$75,291
														Subtotal = $1,043,317

Issue Date FY: 2010 ( Subtotal = $1,058,840 )
2010	2010	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	8	3/25/2010	NON-COMPETING CONTINUATION	$1,058,840
														Subtotal = $1,058,840

Issue Date FY: 2009 ( Subtotal = $1,052,036 )
2009	2009	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	7	4/17/2009	NON-COMPETING CONTINUATION	$1,052,036
														Subtotal = $1,052,036

Issue Date FY: 2008 ( Subtotal = $1,019,072 )
2008	2008	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	6	5/19/2008	COMPETING CONTINUATION	$1,019,072
														Subtotal = $1,019,072

Issue Date FY: 2007 ( Subtotal = $1,017,258 )
2007	2007	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	5	5/30/2007	NON-COMPETING CONTINUATION	$1,017,258
														Subtotal = $1,017,258

Issue Date FY: 2006 ( Subtotal = $997,607 )
2006	2006	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	4	6/5/2006	NON-COMPETING CONTINUATION	$997,607
														Subtotal = $997,607

Issue Date FY: 2005 ( Subtotal = $1,044,653 )
2005	2005	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Drug Use and Addiction Research Programs	000	3	5/26/2005	NON-COMPETING CONTINUATION	$1,044,653
														Subtotal = $1,044,653

Issue Date FY: 2004 ( Subtotal = $983,947 )
2004	2004	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Indicates awards funded from multiple programs	000	2	6/4/2004	NON-COMPETING CONTINUATION	$983,947
														Subtotal = $983,947

Issue Date FY: 2003 ( Subtotal = $1,000,011 )
2003	2003	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Indicates awards funded from multiple programs	000	1	6/17/2003	NEW	$1,000,011
														Subtotal = $1,000,011

Grand Total All Awards = $16,590,823

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Intergenerational Studies Consortium: Understanding Mechanisms of Family Substance Use Transmission and Effects of Marijuana Legalization

Award Number: R01DA015485

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/20/2003

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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