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SOCIAL STRESS: VULNERABILITY TO COCAINE ABUSE IN MONKEYS

Award Number: R01DA010584
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/1996
PERIOD OF PERFORMANCE END DATE: 06/30/2010

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SOCIAL STRESS: VULNERABILITY TO COCAINE ABUSE IN MONKEYS - DESCRIPTION (provided by applicant): The overarching goal of this research is to achieve a better understanding of the individual differences in the susceptibility and vulnerability to the reinforcing effects of cocaine using a unique nonhuman primate model of drug abuse. To accomplish this, we have combined the study of primate social behavior with intravenous drug self-administration and the noninvasive brain imaging procedure positron emission tomography (PET) to examine how environmental and pharmacological variables influence the behavioral and reinforcing effects of cocaine. In the previous funding period we found that social housing altered dopamine (DA) D2 receptor function in male cynomolgus monkeys and these changes were associated with differential vulnerability to self-administer cocaine between dominant and subordinate monkeys. These studies were the first to examine intravenous cocaine self-administration in socially housed monkeys and found that social status and environmental context can have profound effects on cocaine reinforcement. We also found that chronic exposure to cocaine could attenuate the effects of social rank on DA receptor function and result in similar rates of self-administration among the socially housed monkeys. The studies proposed in this competing renewal application are designed to evaluate further the interactions between DA, social rank and the reinforcing effects of cocaine. Specifically, we propose to 1) examine further the plasticity of the DA system during cocaine abstinence and following social group reorganization and assess the impact of these manipulations on cocaine reinforcement; 2) determine the effects of social consequences of self-administering cocaine on the reinforcing effects of the drug and on measures of impulsivity; and 3) examine further the interactions between acute and chronic environmental stressors and enrichment on DA receptor function and on the reinforcing effects of cocaine, as a function of social rank. The use of novel and homologous nonhuman primate models of cocaine abuse, as proposed, should aid in understanding how environmental and pharmacological variables contribute to vulnerability, maintenance, relapse and choice behavior involving drugs of abuse. Such information will lead to better treatment and prevention strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $414,572 )
2005	2005	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	9	6/21/2005	COMPETING CONTINUATION	$414,572
														Subtotal = $414,572

Issue Date FY: 2004 ( Subtotal = $406,780 )
2004	2004	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	8	2/26/2004	NON-COMPETING CONTINUATION	$406,780
														Subtotal = $406,780

Issue Date FY: 2003 ( Subtotal = $394,934 )
2003	2003	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	7		NON-COMPETING CONTINUATION	$394,934
														Subtotal = $394,934

Issue Date FY: 2002 ( Subtotal = $384,093 )
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	6	1/16/2002	NON-COMPETING CONTINUATION	$384,093
														Subtotal = $384,093

Issue Date FY: 2001 ( Subtotal = $374,205 )
2001	2001	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	5	1/19/2001	NON-COMPETING CONTINUATION	$374,205
														Subtotal = $374,205

Issue Date FY: 2000 ( Subtotal = $363,930 )
2000	2000	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	4	2/3/2000	COMPETING CONTINUATION	$363,930
														Subtotal = $363,930

Issue Date FY: 1999 ( Subtotal = $7,290 )
1999	1999	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	001	3	6/22/1999	SUPPLEMENT FOR EXPANSION	$7,290
														Subtotal = $7,290

Issue Date FY: 1998 ( Subtotal = $344,322 )
1998	1998	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	3	7/29/1998	NON-COMPETING CONTINUATION	$344,322
														Subtotal = $344,322

Grand Total All Awards = $2,690,126

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SOCIAL STRESS: VULNERABILITY TO COCAINE ABUSE IN MONKEYS

Award Number: R01DA010584

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/1996

PERIOD OF PERFORMANCE END DATE: 06/30/2010

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