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Developmental Effects of Prenatal Cocaine Exposure

Award Number: R01DA007109
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1992
PERIOD OF PERFORMANCE END DATE: 04/30/2015

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Developmental Effects of Prenatal Cocaine Exposure - DESCRIPTION (provided by applicant): This Revision Application is in response to NOT-OD-10-032: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (R01, R03, R15, R21, R21/R33, and R37) through the NIH Basic Behavioral and Social Science Opportunity Network (OppNet). There are few prospective studies directly assessing the impact of stress responsivity on later psychological adjustment. To fill this critical gap, this study seeks to examine early and later cortisol response to stress on its relation to psychological adjustment in a sample of low income, inner-city adolescents. This proposal involves the examination of longitudinal data from an ongoing study, "Developmental Effects of Prenatal Cocaine Exposure" (R01 DA07109), as well as the addition of new data. The original aims of the parent grant focused on the developmental effects of prenatal cocaine exposure. In this study, we will expand the original scope of the parent grant to address broader questions relating to the impact of high risk environments from which this sample is taken. For this proposal, given the time constraints and the nature of the problem, we will examine only those children in our sample who were not exposed to cocaine in utero. The proposed study will accomplish several important goals. First, we will examine how early cortisol response to stress impacts on subsequent psychological adjustment. We will examine whether individual patterns of cortisol response precede the onset of emotional and behavioral problems by analyzing data previously collected at 8 time points from ages 4 to 13 and collecting new measures of stress and psychological adjustment at age 17. Second, we will examine whether early cortisol response to stress is related to later cortisol response to stress. Few studies have examined individual patterns of cortisol response to stress within or across developmental periods early in life, and the results from these are inconsistent. Thus, we will be able to investigate both developmental change and variation in HPA activity over time, using novel analytic models of continuity and change. Our third aim is to determine whether later cortisol response to stress mediates the relation between early cortisol response and later psychological adjustment. Preliminary studies have shown that the Trier Social Stress Test for Children (TSST-C) is both age- appropriate and effective in eliciting a stress response. In a pilot study, mean cortisol levels increased after administration of the TSST-C. Preliminary data analyses at earlier ages indicate that there are important individual differences in cortisol reactivity as well as variability in measures of subsequent psychological adjustment among this subsample of adolescents from low-income, inner-city environments. Few other studies have integrated HPA response to acute stress and psychological health within a prospective longitudinal design. In addition, few studies have examined age-related changes in patterns of HPA axis reactivity within a low-income, inner-city adolescent population, taking environmental risk into account.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	21	3/26/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2014	2012	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	21	12/23/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$5,366
2014	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	20	12/23/2013	NON-COMPETING CONTINUATION	$5,366
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	20	7/26/2013	NON-COMPETING CONTINUATION	-$791,524
2013	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	20	7/26/2013	SUPPLEMENT FOR EXPANSION	-$5,980
2013	2012	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Drug Use and Addiction Research Programs	002	21	7/26/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$797,504
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $797,504 )
2012	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	20	5/23/2012	SUPPLEMENT FOR EXPANSION	$5,980
2012	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	20	4/12/2012	NON-COMPETING CONTINUATION	$791,524
														Subtotal = $797,504

Issue Date FY: 2011 ( Subtotal = $827,498 )
2011	2011	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	19	5/3/2011	NON-COMPETING CONTINUATION	$822,598
2011	2011	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	19	6/7/2011	SUPPLEMENT FOR EXPANSION	$4,900
														Subtotal = $827,498

Issue Date FY: 2010 ( Subtotal = $826,418 )
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	003	18	6/1/2010	SUPPLEMENT FOR EXPANSION	$2,930
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	18	5/6/2010	NON-COMPETING CONTINUATION	-$823,488
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	18	5/11/2010	NON-COMPETING CONTINUATION	$823,488
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	18	5/4/2010	NON-COMPETING CONTINUATION	$823,488
														Subtotal = $826,418

Issue Date FY: 2009 ( Subtotal = $807,654 )
2009	2009	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	17	4/21/2009	NON-COMPETING CONTINUATION	$807,654
														Subtotal = $807,654

Issue Date FY: 2008 ( Subtotal = $812,361 )
2008	2008	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	16	6/24/2008	COMPETING CONTINUATION	$812,361
														Subtotal = $812,361

Issue Date FY: 2007 ( Subtotal = $71,221 )
2007	2007	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	15	9/25/2007	SUPPLEMENT FOR EXPANSION	$71,221
														Subtotal = $71,221

Issue Date FY: 2006 ( Subtotal = $1,181,356 )
2006	2006	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	15	6/30/2006	NON-COMPETING CONTINUATION	$1,173,296
2006	2006	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	14	6/29/2006	SUPPLEMENT FOR EXPANSION	$8,060
														Subtotal = $1,181,356

Issue Date FY: 2005 ( Subtotal = $1,122,800 )
2005	2005	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	14	7/1/2005	NON-COMPETING CONTINUATION	$1,122,800
														Subtotal = $1,122,800

Issue Date FY: 2004 ( Subtotal = $1,133,150 )
2004	2004	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	12	3/22/2004	SUPPLEMENT FOR EXPANSION	$40,603
2004	2004	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	13	7/12/2004	NON-COMPETING CONTINUATION	$1,092,547
														Subtotal = $1,133,150

Issue Date FY: 2003 ( Subtotal = $968,293 )
2003	2003	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	12	7/21/2003	NON-COMPETING CONTINUATION	$968,293
														Subtotal = $968,293

Issue Date FY: 2002 ( Subtotal = $983,990 )
2002	2002	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	11	9/26/2002	COMPETING CONTINUATION	$983,990
														Subtotal = $983,990

Issue Date FY: 2001 ( Subtotal = $859,211 )
2001	2001	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	10	9/6/2001	NON-COMPETING CONTINUATION	$859,211
														Subtotal = $859,211

Issue Date FY: 2000 ( Subtotal = $950,288 )
2000	2000	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	9	9/12/2000	NON-COMPETING CONTINUATION	$950,288
														Subtotal = $950,288

Issue Date FY: 1999 ( Subtotal = $906,574 )
1999	1999	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	7	7/22/1999	SUPPLEMENT FOR EXPANSION	$6,899
1999	1999	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	8	8/31/1999	NON-COMPETING CONTINUATION	$799,982
1999	1999	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	7	4/13/1999	SUPPLEMENT FOR EXPANSION	$60,574
1999	1999	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	8	9/25/1999	SUPPLEMENT FOR EXPANSION	$39,119
														Subtotal = $906,574

Issue Date FY: 1998 ( Subtotal = $788,905 )
1998	1998	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	7	8/27/1998	NON-COMPETING CONTINUATION	$779,055
1998	1998	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	6	7/6/1998	SUPPLEMENT FOR EXPANSION	$9,850
														Subtotal = $788,905

Grand Total All Awards = $13,037,223

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Developmental Effects of Prenatal Cocaine Exposure

Award Number: R01DA007109

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1992

PERIOD OF PERFORMANCE END DATE: 04/30/2015

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