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SYNTHESIS OF DELTA9-TETRAHYDROCANNABINOL RELATED COMPOUNDS

Award Number: R01DA005488
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/1988
PERIOD OF PERFORMANCE END DATE: 07/31/2012

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SYNTHESIS OF DELTA9-TETRAHYDROCANNABINOL RELATED COMPOUNDS - DESCRIPTION (provided by applicant): The drug abuse problem in general and the wide spread use of marijuana in particular has focused attention on the chemistry and pharmacology of cannabinoids. Although rapid advances have been made in the chemistry and pharmacology of this class of compounds, the mechanisms involved in producing the various central nervous effects (CNS) have not been established. The long term goal of the synthetic program is to develop A9-tetrahydrocannabinol (THC) analogs which will prove to be useful tools in elucidating the mechanism of action of cannabinoids. The present emphasis will be directed towards: (a) development of CB1 selective agonists (b) development of allosteric modulators of the cannabinoid CB1 receptors (c) studying peripheral acting agonists and antagonists (d) elucidation of ligand-CB1 receptor iterations (e) development of CB1 neutral antagonist/inverse agonists which are structurally related to THC and (f) generation of new biological leads. All these goals represent a continuation of the current program which has generated several noteworthy leads. The specific aims are (1) development of CB1 selective agonists, (2) development of allosteric modulators of the CB1 receptors, (3) examining peripheral acting agonists and antagonists, (4) elucidation of ligand-CB1 receptor interactions, (5) development of CB1 neutral/inverse agonists which are structurally related to THC, and (6) generate new biological leads. The knowledge gained from the synthesis and pharmacological study of these analogs could be vital in the study of Structure Activity Relationships(SAR), tolerance, dependence and in the development of therapeutically useful drugs, and will lead to a better understanding of the mechanism of action of cannabinoids and will help combat the problem of drug abuse.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $337,617 )
2011	2011	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	24	6/27/2011	NON-COMPETING CONTINUATION	$337,617
														Subtotal = $337,617

Issue Date FY: 2010 ( Subtotal = $348,059 )
2010	2010	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	23	7/1/2010	NON-COMPETING CONTINUATION	$348,059
														Subtotal = $348,059

Issue Date FY: 2009 ( Subtotal = $351,575 )
2009	2009	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	22	6/19/2009	NON-COMPETING CONTINUATION	$351,575
2009	2008	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	21	12/8/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $351,575

Issue Date FY: 2008 ( Subtotal = $351,575 )
2008	2008	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	21	7/9/2008	NON-COMPETING CONTINUATION	$351,575
														Subtotal = $351,575

Issue Date FY: 2007 ( Subtotal = $358,750 )
2007	2007	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	20	8/3/2007	COMPETING CONTINUATION	$358,750
														Subtotal = $358,750

Issue Date FY: 2006 ( Subtotal = $350,320 )
2006	2006	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	19	7/6/2006	NON-COMPETING CONTINUATION	$350,320
														Subtotal = $350,320

Issue Date FY: 2005 ( Subtotal = $358,750 )
2005	2005	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	18	6/27/2005	NON-COMPETING CONTINUATION	$358,750
														Subtotal = $358,750

Issue Date FY: 2004 ( Subtotal = $358,750 )
2004	2004	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	17	7/13/2004	NON-COMPETING CONTINUATION	$358,750
														Subtotal = $358,750

Issue Date FY: 2003 ( Subtotal = $358,750 )
2003	2003	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	16	7/14/2003	NON-COMPETING CONTINUATION	$358,750
														Subtotal = $358,750

Issue Date FY: 2002 ( Subtotal = $358,750 )
2002	2002	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	15	8/9/2002	COMPETING CONTINUATION	$358,750
														Subtotal = $358,750

Issue Date FY: 2001 ( Subtotal = $275,738 )
2001	2001	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	14	6/22/2001	NON-COMPETING CONTINUATION	$275,738
														Subtotal = $275,738

Issue Date FY: 2000 ( Subtotal = $267,704 )
2000	2000	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	13	7/20/2000	NON-COMPETING CONTINUATION	$267,704
														Subtotal = $267,704

Issue Date FY: 1999 ( Subtotal = $259,907 )
1999	1999	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	12	6/11/1999	NON-COMPETING CONTINUATION	$259,907
														Subtotal = $259,907

Issue Date FY: 1998 ( Subtotal = $252,339 )
1998	1998	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	11	6/29/1998	NON-COMPETING CONTINUATION	$252,339
														Subtotal = $252,339

Grand Total All Awards = $4,588,584

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SYNTHESIS OF DELTA9-TETRAHYDROCANNABINOL RELATED COMPOUNDS

Award Number: R01DA005488

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/1988

PERIOD OF PERFORMANCE END DATE: 07/31/2012

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