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Risk Factors for AIDS among Persons Who Inject Drugs: HIV and COVID-19

Award Number: R01DA003574
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/1994
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Risk Factors for AIDS among Persons Who Inject Drugs: HIV and COVID-19 - Abstract It is difficult to underestimate the potential public health significance of the COVID-19 pandemic for generating new outbreaks of HIV among PWID. While public health scale implementation of “combined prevention and care for HIV” among PWID has led to dramatic reductions in HIV transmission in many high-income countries, multiple outbreaks of HIV have also occurred, e.g., in the US, Western and Eastern Europe, and Israel. While there were distinct features of each outbreak, a number of common features were noted across the outbreaks, including: 1) community economic dislocations, 2) inadequate or interrupted HIV prevention services, 3) local introduction of new injectable drugs, and 4) homeless PWID as a very high-risk group. The COVID-19 pandemic and its associated lockdown/control measures appear to be re-creating the very conditions that generated HIV outbreaks among PWID in the pre- COVID-19 era. The recent FDA emergency use authorization of effective SARS-CoV-2 vaccines provides a critical opportunity to alleviate some—but certainly not all—of the threats to HIV prevention. However, important potential difficulties in rapidly vaccinating large numbers of PWID exist. We propose to examine relationships between HIV, COVID-19, and racial/ethnic disparities among PWID in NYC, a location that has experienced the world’s largest local HIV epidemic among PWID, and one of the world’s largest local COVID-19 epidemics, through four specific aims: 1. Assess short term (within 3 years) impact of the COVID-19 pandemic on HIV risk among PWID in NYC, including potential increases in critical bio-behavioral risks (composite risk for HIV transmission and composite multi-person risk for HIV acquisition). 2. Monitor SARS-CoV-2 vaccination over time among PWID in NYC. Identify factors associated with receiving vaccination, including ‘underlying health conditions,” socio-demographics, particularly race/ethnicity and employment, vaccine awareness and attitudes, and across patterns of drug use. Examine peer, family and “trusted sources” influences on receiving vaccination. Educate participants on SARS-CoV-2 vaccines, including availability, types, side effects and scheduling. Assess the extent to which “herd immunity” is being achieved among PWID. 3. Utilize antibody testing to estimate past and incident COVID-19 infection among PWID, identifying risk factors for infection, including race/ethnicity, and whether practicing protective behaviors is associated with lower seroprevalence. 4. Using principal component analysis (PCA), examine relationships between multiple health problems and social determinants of health among PWID in NYC, including HIV, COVID-19, HCV, opioid and stimulant use, drug overdose, homelessness, and economic and food insecurity, during the COVID-19 pandemic. Examine patterns of racial/ethnic disparities among the clusters of health and social determinants of health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	000	39	5/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $766,391 )
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	001	39	6/9/2023	NON-COMPETING CONTINUATION	$767,023
2023	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	000	36	11/21/2022	NON-COMPETING CONTINUATION	-$632
														Subtotal = $766,391

Issue Date FY: 2022 ( Subtotal = $776,533 )
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	002	38	6/15/2022	NON-COMPETING CONTINUATION	$776,533
2022	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	001	37	12/10/2021	COMPETING CONTINUATION	$487,501
2022	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	000	36	12/7/2021	NON-COMPETING CONTINUATION	-$487,501
														Subtotal = $776,533

Issue Date FY: 2021 ( Subtotal = $792,422 )
2021	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	002	37	7/9/2021	COMPETING CONTINUATION	$792,422
2021	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	000	36	12/16/2020	NON-COMPETING CONTINUATION	$0
2021	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	001	36	7/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $792,422

Issue Date FY: 2019 ( Subtotal = $612,364 )
2019	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	002	36	1/31/2019	NON-COMPETING CONTINUATION	$639,394
2019	2018	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	001	35	11/2/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$389,480
2019	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	004	34	7/9/2019	NON-COMPETING CONTINUATION	-$267,258
2019	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	000	34	11/2/2018	NON-COMPETING CONTINUATION	-$416,510
2019	2018	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Drug Use and Addiction Research Programs	005	35	7/9/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$937,478
2019	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	003	33	7/9/2019	NON-COMPETING CONTINUATION	-$670,220
														Subtotal = $612,364

Issue Date FY: 2018 ( Subtotal = $683,768 )
2018	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	001	34	4/26/2018	NON-COMPETING CONTINUATION	$68,378
2018	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	000	34	1/12/2018	NON-COMPETING CONTINUATION	$615,390
														Subtotal = $683,768

Issue Date FY: 2017 ( Subtotal = $697,615 )
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	000	33	1/10/2017	NON-COMPETING CONTINUATION	$627,852
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	003	33	5/22/2017	NON-COMPETING CONTINUATION	$69,763
2017	2016	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Drug Use and Addiction Research Programs	002	32	5/2/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$725,100
2017	2015	BETH ISRAEL MEDICAL CENTER	FIRST AVE 16TH ST	NEW YORK	NY	10003	NEW YORK	USA	Drug Use and Addiction Research Programs	001	31	5/2/2017	COMPETING CONTINUATION	-$725,100
														Subtotal = $697,615

Issue Date FY: 2016 ( Subtotal = $690,640 )
2016	2016	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Drug Use and Addiction Research Programs	001	32	4/11/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$690,640
2016	2015	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	31	4/8/2016	COMPETING CONTINUATION	$0
														Subtotal = $690,640

Issue Date FY: 2015 ( Subtotal = $651,735 )
2015	2015	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	31	1/20/2015	COMPETING CONTINUATION	$651,735
														Subtotal = $651,735

Issue Date FY: 2013 ( Subtotal = $619,905 )
2013	2013	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	001	30	5/16/2013	NON-COMPETING CONTINUATION	$38,744
2013	2013	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	30	4/17/2013	NON-COMPETING CONTINUATION	$581,161
														Subtotal = $619,905

Issue Date FY: 2012 ( Subtotal = $652,269 )
2012	2012	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	29	4/13/2012	NON-COMPETING CONTINUATION	$652,269
														Subtotal = $652,269

Issue Date FY: 2011 ( Subtotal = $652,390 )
2011	2011	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	28	6/14/2011	NON-COMPETING CONTINUATION	$652,390
														Subtotal = $652,390

Issue Date FY: 2010 ( Subtotal = $673,378 )
2010	2010	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK	NY	10003	NEW YORK	USA	Drug Use and Addiction Research Programs	000	27	4/16/2010	NON-COMPETING CONTINUATION	$673,378
														Subtotal = $673,378

Issue Date FY: 2009 ( Subtotal = $670,338 )
2009	2009	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK	NY	10003	NEW YORK	USA	Drug Use and Addiction Research Programs	000	26	5/12/2009	COMPETING CONTINUATION	$670,338
														Subtotal = $670,338

Issue Date FY: 2008 ( Subtotal = $696,700 )
2008	2008	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	25	6/18/2008	NON-COMPETING CONTINUATION	$696,700
														Subtotal = $696,700

Issue Date FY: 2007 ( Subtotal = $683,636 )
2007	2007	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	24	7/5/2007	NON-COMPETING CONTINUATION	$683,636
														Subtotal = $683,636

Issue Date FY: 2006 ( Subtotal = $800,792 )
2006	2006	BETH ISRAEL MEDICAL CENTER	FIRST AVE AT 16TH STREET	NEW YORK-NEW YORK	NY	10003		USA	Drug Use and Addiction Research Programs	000	23	6/14/2006	NON-COMPETING CONTINUATION	$800,792
														Subtotal = $800,792

Grand Total All Awards = $17,565,013

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Risk Factors for AIDS among Persons Who Inject Drugs: HIV and COVID-19

Award Number: R01DA003574

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/1994

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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