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A Patient-Specific Magnetic Resonance Guided Focused Ultrasound System for Breast Cancer Treatment

Award Number: R01CA305900
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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A Patient-Specific Magnetic Resonance Guided Focused Ultrasound System for Breast Cancer Treatment - ABSTRACT (PAYNE) Breast cancer is the second most common cancer among American women, and most of these women (~64%) will be diagnosed at an early stage when the cancer is still localized to the breast. Surgery is often the treatment of choice for most early-stage breast cancer patients, as it is typically a curative treatment option when combined with radiation, chemotherapy or hormone therapy as indicated by the tumor subtype. Treatment selection by the patient and clinical team encompasses many factors, including surgical side effects such as aesthetic outcomes and pain. There remains a need for more conservative, more efficacious, and less invasive breast cancer treatment options for early-stage breast cancer patients. This proposal seeks to address these issues through the development of a magnetic resonance guided focused ultrasound (MRgFUS) system that can non-invasively treat breast cancer through both thermally ablative and non-ablative techniques. This proposed system re-envisions the potential of breast MRI and MRgFUS with the goal of achieving efficacious thermal ablation under diagnostic-quality MRI, while prioritizing the patient’s experience and comfort. The goal of construction and validation of a patient-specific, next generation breast MRgFUS system will be achieved in three specific aims. Aim 1: Construct a patient-specific next generation breast MRgFUS system that enables an individualized experience, with the required signal-to-noise ratio to support high accuracy and precision MR temperature imaging and MRgFUS thermal ablation treatment monitoring. Aim 2: Optimize and validate a MRgFUS hyperthermia controller specifically for breast cancer patients. Aim 3: Evaluate imaging and treatment of the new breast MRgFUS system in a treat and resect feasibility clinical trial where both ablative and non-ablative conditions will be evaluated. The successful achievement of the defined aims will result in a breast MRgFUS system that can deliver highly controlled ablative and non-ablative thermal exposures and has undergone the validation required for future phase II clinical trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $625,791 )
2026	2026	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Detection and Diagnosis Research	000	1	5/28/2026	NEW	$625,791
														Subtotal = $625,791

Grand Total All Awards = $625,791

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A Patient-Specific Magnetic Resonance Guided Focused Ultrasound System for Breast Cancer Treatment

Award Number: R01CA305900

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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