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Functional Avoidance Liver Stereotactic Body Radiation Therapy Guided by MR Multitasking-driven Abdominal Integrated Imaging (MT-AI2)

Award Number: R01CA301509
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Functional Avoidance Liver Stereotactic Body Radiation Therapy Guided by MR Multitasking-driven Abdominal Integrated Imaging (MT-AI2) - ABSTRACT Radiation plays an important role in treating primary and secondary liver tumors. Stereotactic body radiation therapy (SBRT) has become a standard treatment in the model era. However, toxicity-inducing doses to the normal liver often accompany the high biologically effective dose to the tumor, so radiation-induced liver disease (RILD) is a common complication that can be fatal to patients. As patient survival rates rise and therapeutic options expand, SBRT aims not only to ablate tumors but also to reduce radiation exposure to functional liver voxels, thereby decreasing treatment-related toxicities to maintain hepatic function and support future interventions, such as liver transplantation. Functional Avoidance SBRT (FA-SBRT) has been proposed. Researchers have created FA-SBRT plans using commercial planning systems. However, it was concluded there was insufficient data to confirm efficacy. The inability to establish the efficacy can be attributed to the following reasons: the lack of clinically accessible methods to assess voxel-level liver function, the lack of quantifiable liver function metrics for treatment planning, and the severe limitations of commercial planning systems in achieving a more significant level of functional liver sparing. We pioneered the development of a Multi-Tasking (MT) MR imaging sequence and advanced non-coplanar 4π planning method. The convergence of cutting-edge imaging and plan optimization strategies presents an unparalleled opportunity to optimize treatment delivery, reduce radiation-induced liver toxicity, and augment therapeutic outcomes. The proposal directly responds to PAR-25- 145, Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies. The three proposed aims are 1. To develop and optimize the MR multi-tasking abdominal integrated imaging (MT-AI2); 2. To create a functional avoidance SBRT planning strategy using advanced 4π optimization; 3. To conduct a phase II clinical trial to test efficacy. The project’s success will demonstrate the effectiveness of integrating cutting-edge imaging and therapeutic methods to maximally preserve liver function for future treatment options.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $700,838 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Detection and Diagnosis Research	000	1	3/12/2026	NEW	$700,838
														Subtotal = $700,838

Grand Total All Awards = $700,838

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Functional Avoidance Liver Stereotactic Body Radiation Therapy Guided by MR Multitasking-driven Abdominal Integrated Imaging (MT-AI2)

Award Number: R01CA301509

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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