Monday, June 30, 2025 6/30/2025

Molecular Functions of BRCA2 and RAD51 Paralogs in Homologous Recombination and Chromosome Maintenance

Award Number: R01CA293029
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/10/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

Group Awards By:

View Award Description

Molecular Functions of BRCA2 and RAD51 Paralogs in Homologous Recombination and Chromosome Maintenance - Project Summary/Abstract The broad objective of this proposal is to understand the molecular mechanism of homologous recombination (HR) in humans, and to understand how the consequences of defects in recombinational DNA repair result in chromosomal instability that underlie the predisposition to cancers. The proteins involved in a central step of HR, DNA pairing, include RAD51, BRCA2, and the RAD51 paralogs, RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3. Mutations in these proteins are known to predispose individuals to cancer. The objective is to understand the functions of these proteins in genome maintenance via recombinational DNA repair, and how these proteins mediate and potentiate homologous DNA pairing by RAD51. We propose to understand their mechanisms of action through biochemical analyses of reconstituted reactions using purified proteins; characterization of defective mutant proteins identified in the patient population, and by visualizing the individual behavior of these proteins acting on single molecules of DNA. The Specific Aims are to understand the molecular functions of BRCA2 protein and to determine the functions of the RAD51 paralogs in RAD51 filament formation and RAD51-dependent DNA pairing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $368,288 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	2	6/12/2025	NON-COMPETING CONTINUATION	$368,288
														Subtotal = $368,288

Issue Date FY: 2024 ( Subtotal = $368,288 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	1	7/10/2024	NEW	$368,288
														Subtotal = $368,288

Grand Total All Awards = $736,576

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Molecular Functions of BRCA2 and RAD51 Paralogs in Homologous Recombination and Chromosome Maintenance

Award Number: R01CA293029

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/10/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer