Tuesday, July 1, 2025 7/1/2025

Non-canonical function of transcription cofactor MLL1 in cancer

Award Number: R01CA287625
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Non-canonical function of transcription cofactor MLL1 in cancer - Project Summary Aberrations of chromatin modifying enzymes are frequently found in a wide spectrum of human diseases. Among them, histone H3 K4 methyltransferase mixed lineage leukemia (MLL1, also called KMT2A) has been extensively studied in cancer. MLL1 rearrangement is common in acute pediatric leukemia, in which translocation of one MLL1 allele gives rise to an oncogenic fusion protein. Other MLL1 mutations, including amplification and overexpression, are commonly found in multiple cancers with unknown etiology. MLL1 resides in a multi-subunit complex with conserved components shared among other KMT2 family enzymes, and together they regulate global histone H3K4 methylation. While most studies focus on MLL1’s role in transcription via canonical H3K4 methylation, MLL1 also has non-canonical functions in regulating important cellular processes. We will use multidisciplinary approaches to gain new mechanistic insights on how MLL1 affects cancer development through transcription dependent and independent activities and evaluate its potential as a therapeutic target in hepatocellular carcinoma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $510,646 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Biology Research	002	2	6/4/2025	NON-COMPETING CONTINUATION	$51,065
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Biology Research	000	2	1/8/2025	NON-COMPETING CONTINUATION	$459,581
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Biology Research	001	2	2/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $510,646

Issue Date FY: 2024 ( Subtotal = $509,877 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Biology Research	000	1	1/25/2024	NEW	$509,877
														Subtotal = $509,877

Grand Total All Awards = $1,020,523

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Non-canonical function of transcription cofactor MLL1 in cancer

Award Number: R01CA287625

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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