Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Single-cell congruence evaluation and selection of cancer models towards precision medicine

Award Number: R01CA285337
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/03/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2030

Group Awards By:

View Award Description

Single-cell congruence evaluation and selection of cancer models towards precision medicine - Abstract Cancer models, such as cell lines, patient-derived xenograft (PDX) and patient-derived organoids (PDO), are instrumental substitutes for human studies in cancer research. Whether a specific cancer model mimics tumors in human patients and how to quantify the congruence are urgent and unsettled questions. With an increasing number of cancer models available, how to authenticate and select the most representative model using molecular profile information is an emerging issue. In the literature, nascent approaches are appearing through association-based or machine-learning-based approaches. While providing partial answers, existing tools have significant shortcomings that limit the potentials of rich cancer model resources towards translational and preclinical research. To decipher congruence evaluation at the level of intratumor heterogeneity and tumor microenvironment, we propose a comprehensive framework to determine molecular credentials and selection of cancer models and to guide translational and clinical applications using single-cell RNA-seq data. The specific aims are: (1) Identify and clinically annotate prevalent subclones and tumor microenvironment cell types in breast cancer. (2) Perform subclone-based congruence and selection for cancer models. (3) Decipher temporal changes in congruence of patient-derived models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $576,594 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Biology Research	001	2	4/16/2026	NON-COMPETING CONTINUATION	$57,659
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Biology Research	000	2	1/28/2026	NON-COMPETING CONTINUATION	$518,935
														Subtotal = $576,594

Issue Date FY: 2025 ( Subtotal = $585,931 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Biology Research	000	1	2/3/2025	NEW	$585,931
														Subtotal = $585,931

Grand Total All Awards = $1,162,525

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Single-cell congruence evaluation and selection of cancer models towards precision medicine

Award Number: R01CA285337

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/03/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer