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Improving risk stratification for lung cancer screening using peripheral blood leukocyte DNA methylation: an investigation in the National Lung Screening Trial (NLST)

Award Number: R01CA280815
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2028

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Improving risk stratification for lung cancer screening using peripheral blood leukocyte DNA methylation: an investigation in the National Lung Screening Trial (NLST) - Lung cancer is the leading cause of cancer death in the US, accounting for approximately 22% of all cancer deaths. Annual screening with low-dose computed tomography (LDCT) is recommended in adults aged 50-80 years who have a history of pack-years to 20 and are current smokers or quit in the past 15 years, but screening with LDCT remains controversial due to the very high false-positive rates, increased radiation exposures, and costs. Moreover, many adults are diagnosed with lung cancer who are not eligible for screening. In the 2021 USPSTF recommendation statement, the task force identified “Future Research Needs,” which includes conducting more research on biomarkers, noting that: “Biomarkers could potentially be used to identify high-risk candidates for screening with LDCT”. For this project, we propose to measure DNA methylation levels in blood leukocytes obtained from samples that were collected prior to screening (and at multiple time points) in participants of the National Lung Screening Trial (NLST). Our first objective is to develop a pre-screening tool that would classify high-risk participants into additional risk categories to reduce number of scans needed. Our second objective is to examine whether differences in DNA methylation markers can distinguish participants with positive screening results who developed lung cancer from those with false positives (i.e., did not develop cancer). Our third objective is to examine whether differences in DNA methylation markers can discriminate participants who had a negative scan and were diagnosed with lung cancer during follow-up and through the end of 2014 from those with a negative scan who did not develop lung cancer. Using the NLST archived samples will allow us to efficiently evaluate whether DNA methylation markers can improve models for risk stratification, thus reduce unnecessary scans needed to be performed, as well as potentially assist in identifying true positive and false negative LDCT scans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $662,505 )
2026	2026	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Cancer Cause and Prevention Research	000	3	3/6/2026	NON-COMPETING CONTINUATION	$662,505
														Subtotal = $662,505

Issue Date FY: 2025 ( Subtotal = $676,338 )
2025	2025	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Cancer Cause and Prevention Research	001	2	5/28/2025	NON-COMPETING CONTINUATION	$67,633
2025	2025	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Cancer Cause and Prevention Research	000	2	2/13/2025	NON-COMPETING CONTINUATION	$608,705
														Subtotal = $676,338

Issue Date FY: 2024 ( Subtotal = $722,370 )
2024	2024	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Cancer Cause and Prevention Research	000	1	2/26/2024	NEW	$722,370
														Subtotal = $722,370

Grand Total All Awards = $2,061,213

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Improving risk stratification for lung cancer screening using peripheral blood leukocyte DNA methylation: an investigation in the National Lung Screening Trial (NLST)

Award Number: R01CA280815

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2028

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