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AI enhanced lifetime-based mesoscopic in vivo imaging of tissue molecular heterogeneity

Award Number: R01CA271371
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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AI enhanced lifetime-based mesoscopic in vivo imaging of tissue molecular heterogeneity - Abstract Quantification of drug-target engagement is recognized as the most crucial parameter in the drug development pipeline as it is central to therapeutic action. Though, such parameter can only be assessed via invasive biochemical and immunohistochemical (IHC) approaches in ex vivo tissues. Herein, we propose to integrate and optimize a multimodal optical imaging platform that can provide direct longitudinal (multiple time points) measurements of the drug-target engagement distribution across the same tissue volume in correlation with drug delivery efficacy parameters, including, tumor vasculature, and indicators of drug response, such as metabolism. The imaging platform will be validated in human breast tumor and patient derived xenografts in live animals subjected to HER2-trastuzumab therapy. Additionally, as MFMT is an indirect image formation technique relying on complex computational tasks, we will further pioneer the use of Deep Learning methodologies for fast, accurate, parameter-free and user friendly 2D and 3D MFMT image formation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $651,479 )
2025	2025	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Biology Research	000	3	6/11/2025	NON-COMPETING CONTINUATION	$651,479
														Subtotal = $651,479

Issue Date FY: 2024 ( Subtotal = $618,698 )
2024	2024	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Biology Research	000	2	5/9/2024	NON-COMPETING CONTINUATION	$618,698
														Subtotal = $618,698

Issue Date FY: 2023 ( Subtotal = $660,757 )
2023	2023	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Biology Research	000	1	5/19/2023	NEW	$660,757
														Subtotal = $660,757

Grand Total All Awards = $1,930,934

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AI enhanced lifetime-based mesoscopic in vivo imaging of tissue molecular heterogeneity

Award Number: R01CA271371

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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