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An integrated community-clinic model of optimized implementation strategies to increase early detection of breast and cervical cancers in Kenya

Award Number: R01CA269472
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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An integrated community-clinic model of optimized implementation strategies to increase early detection of breast and cervical cancers in Kenya - PROJECT SUMMARY/ABSTRACT Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late- stage disease. Implementing effective programs to screen and detect these cancers at an early stage could substantially decrease the high mortality. Kenya has been increasing access to cancer screening, but less than one-sixth of eligible women have ever received breast and cervical cancer screening. The goal of the study is to assess the effectiveness and cost-effectiveness of multicomponent strategies to increase the uptake of breast and cervical cancer screeening. A key gap that perpetuates the low screening rates in Kenya is the lack of community–clinic linkages. There is evidence that women are often unaware of the screening services offered in facilities, and, even among those who are aware, there is lack of motivation, anticipated or perceived stigma, and reduced self-efficacy to undergo screening. We will conduct a pragmatic cluster randomized trial to evaluate the screening outcomes, including screening uptake, diagnostic test completion, and treatment initiation and implementation outcomes to support scale- up. We will test two multicomponent packages of strategies: (1) Cancer Community–Clinic Linkage (C3Link) Core: Community health volunteer (CHV)-delivered group education for women and family members to increase screening uptake in the community setting and practice facilitation to improve the screening process and develop team-based care with CHV participation in the clinic setting; (2) C3Link Plus: C3Link Core strategies along with a sequential series of individual strategies that increase in intensity at 3-month intervals; women who remain unscreened will first receive one-on-one education; second, motivational interviewing; and, finally, navigation to address specific barriers. We will implement the study across 27 communities in Kenya to address the following three specific aims: Aim 1: Conduct a cluster randomized trial to assess short-term (intervention implementation phase) and longer-term impacts (maintenance phase) of the two packages of multicomponent strategies on breast and cervical cancer screening outcomes along the continuum of care compared to enhanced standard of care (communities receiving a messaging campaign only); Aim 2: Use a mixed-methods approach to assess and compare multilevel implementation outcomes of the package of strategies focusing on acceptability, feasibility, appropriateness, fidelity, and sustainability; Aim 3: Perform cost-effectiveness and return-on- investment analysis to support scale-up of an effective package of implementation strategies across Kenya and other sub-Saharan African countries. The Kenyan Ministry of Health can use the findings from this study to design optimal approaches and plan investments in screening infrastructure to scale up implementation of guideline recommendations. The lessons learned can be applied to other sub-Saharan African settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $586,692 )
2025	2025	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	001	4	9/18/2025	NON-COMPETING CONTINUATION	$35,462
2025	2025	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	002	4	9/19/2025	SUPPLEMENT FOR EXPANSION	$23,207
2025	2025	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	000	4	1/23/2025	NON-COMPETING CONTINUATION	$528,023
														Subtotal = $586,692

Issue Date FY: 2024 ( Subtotal = $561,243 )
2024	2024	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	004	3	4/17/2024	NON-COMPETING CONTINUATION	$29,541
2024	2024	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	001	3	1/29/2024	NON-COMPETING CONTINUATION	$531,702
2024	2023	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	000	2	10/24/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2023	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	003	2	3/22/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$92,485
2024	2023	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Cancer Cause and Prevention Research	002	1	3/22/2024	NEW	-$92,485
														Subtotal = $561,243

Issue Date FY: 2023 ( Subtotal = $609,791 )
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cancer Cause and Prevention Research	002	1	5/25/2023	NEW	$0
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cancer Cause and Prevention Research	003	1	8/16/2023	NEW	-$458,930
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cancer Cause and Prevention Research	001	1	4/13/2023	NEW	$0
2023	2023	IMPLENOMICS LLCS	21 MAY STREET	MARBLEHEAD	MA	01945	ESSEX	USA	Cancer Cause and Prevention Research	004	2	8/16/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$463,808
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Cancer Cause and Prevention Research	000	1	1/31/2023	NEW	$604,913
														Subtotal = $609,791

Grand Total All Awards = $1,757,726

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An integrated community-clinic model of optimized implementation strategies to increase early detection of breast and cervical cancers in Kenya

Award Number: R01CA269472

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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