Wednesday, July 30, 2025 7/30/2025

Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy

Award Number: R01CA258827
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy - Cancers that depend on the spatial location of the disease affect all ethnicities and age groups, accounting for significant mortality and therapy-related side effects. In one instance, over 50,000 new cases of head and neck squamous carcinomas are diagnosed each year in the United States, leading to large, rich repositories of patient data. For each of these cases, oncologists need to anticipate survival, oncologic, and toxicity outcomes associated with treatment strategies in order to select a treatment which balances efficacy and toxicity. However, despite the wealth of data available, in the clinic decision support for cancer treatment is rudimentary and incorporates only a handful of patient characteristics, largely due to a lack of computational methodology and tools. We propose to construct a novel statistical and computational methodology for longitudinal and personalized treatment decisions over time, with specific application to head and neck cancer therapy planning. Simultaneous incorporation of complex factors---such as radiation dose location with respect to radiosensitive organs or patient reported side effects affecting quality of life---into treatment decisions over the course of cancer therapy requires the development of novel methodology. This methodology is revolutionary in that it is the first in the field to include both imaging and nonimaging data, while taking into account large-scale biological and clinical correlates. The approach is innovative through its leverage of big data repositories and through its unique blend of computational modeling principles from bioengineering and computer science. These methods allow us to incorporate diverse data types and model competing outcomes. From a clinical perspective, this integrative approach is novel in the field of cancer therapy. The resulting clinical decision support methodology will mark a significant advance in biomedical computing because it will be able to identify, for the first time, actionable timepoints for therapy and toxicity modification, based on a patient’s characteristics and quality of life indicators. The empirically-derived treatment decision support methodology developed in this project has the potential to directly improve the standard of care and the quality of life of surviving patients with a grave, often fatal and debilitating illness.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $549,602 )
2025	2025	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	001	5	5/27/2025	NON-COMPETING CONTINUATION	$54,959
2025	2025	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	000	5	2/13/2025	NON-COMPETING CONTINUATION	$494,643
														Subtotal = $549,602

Issue Date FY: 2024 ( Subtotal = $522,123 )
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	001	4	4/16/2024	NON-COMPETING CONTINUATION	$27,480
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	000	4	2/22/2024	NON-COMPETING CONTINUATION	$494,643
														Subtotal = $522,123

Issue Date FY: 2023 ( Subtotal = $469,299 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	001	3	3/1/2023	NON-COMPETING CONTINUATION	$469,299
2023	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	000	2	1/27/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $469,299

Issue Date FY: 2022 ( Subtotal = $654,347 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	003	2	6/22/2022	NON-COMPETING CONTINUATION	$43,971
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	002	2	6/17/2022	SUPPLEMENT FOR EXPANSION	$9,448
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	001	2	3/2/2022	SUPPLEMENT FOR EXPANSION	$106,287
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	000	2	3/1/2022	NON-COMPETING CONTINUATION	$494,641
														Subtotal = $654,347

Issue Date FY: 2021 ( Subtotal = $661,154 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	001	1	9/21/2021	SUPPLEMENT FOR EXPANSION	$71,648
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Detection and Diagnosis Research	000	1	2/24/2021	NEW	$589,506
														Subtotal = $661,154

Grand Total All Awards = $2,856,525

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Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy

Award Number: R01CA258827

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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