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Large scale single-cell gene rearrangement detection with a microfluidic device

Award Number: R01CA251848
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Acute myeloid leukemia (AML) contributes to 32% of all adult leukemia and remains one of the most clinically devastating cancers. Currently, AML diagnosis, risk stratification and treatment selection are mainly based on cytogenetic abnormalities, which suffers from low sensitivity and low resolution. To overcome this technical hurdle, we propose to use single-cell RNAseq with microfluidic devices to generate a molecular version of AML cytogenetic profile including all mRNA abnormalities from a large number of leukemia cells, a technique we have named S-CytoSeq. This molecular S- CytoSeq profiling provides fusion genes (FG) and alternative splicing (AS) profiles at single-cell resolution and will have a significant clinical impact on AML treatment. The ultimate translational goal is to replace conventional cytogenetics with S-CytoSeq.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $259,029 )
2023	2023	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	001	5	9/8/2023	SUPPLEMENT FOR EXPANSION	$259,028
2023	2023	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	000	5	8/18/2023	NON-COMPETING CONTINUATION	$1
														Subtotal = $259,029

Issue Date FY: 2022 ( Subtotal = $624,418 )
2022	2022	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	004	4	9/16/2022	SUPPLEMENT FOR EXPANSION	$263,496
2022	2022	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	003	4	8/31/2022	NON-COMPETING CONTINUATION	$360,922
2022	2021	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	002	3	10/15/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$388,600
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	001	2	10/15/2021	NON-COMPETING CONTINUATION	-$53,768
2022	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	1	10/15/2021	NEW	-$334,832
														Subtotal = $624,418

Issue Date FY: 2021 ( Subtotal = $377,438 )
2021	2021	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	002	3	8/26/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$320,626
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	003	2	8/30/2021	NON-COMPETING CONTINUATION	-$3,044
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	2	7/21/2021	NON-COMPETING CONTINUATION	$377,438
2021	2021	LOMA LINDA UNIVERSITY	11060 ANDERSON ST BLDG MAGAN HALL	LOMA LINDA	CA	92350	SAN BERNARDINO	USA	Cancer Detection and Diagnosis Research	004	3	8/30/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,044
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	001	2	8/26/2021	NON-COMPETING CONTINUATION	-$320,626
														Subtotal = $377,438

Issue Date FY: 2020 ( Subtotal = $377,438 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	1	6/25/2020	NEW	$377,438
														Subtotal = $377,438

Grand Total All Awards = $1,638,323

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Large scale single-cell gene rearrangement detection with a microfluidic device

Award Number: R01CA251848

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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