Friday, September 19, 2025 9/19/2025

In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging

Award Number: R01CA250636
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging - In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging ABSTRACT There is still great need in better characterizing new targeted therapies in vivo, especially prior to clinical translation. In this regard, preclinical molecular imaging is a central tool in the targeted drug development pipeline. However, there is still a lack of integrated imaging platforms that can enable longitudinal (multiple time points) and spatially-resolved monitoring of complex fingerprints including molecular, metabolic and functional signatures in the same tumor/subject. This new integrated multiplexing imaging platform will play a crucial role in the development of the next generation of targeted drugs and elucidating (multi-) drug resistance mechanisms. Recently, we have demonstrated the unique capabilities of optical imaging in quantifying receptor-target engagement in live subjects by leveraging fluorescence lifetime. This outstanding achievement was realized thanks to the combination of instrumental, algorithmic and biochemical innovations to enable, for the first time, whole-body time-resolved optical imaging based on structured light for 2D or 3D Förster resonance energy transfer (FRET) imaging in live subjects. Herein, we will further impact the field of optical preclinical imaging and drug delivery assessment by 1) integrating a cutting-edge high-resolution, time-resolved SPAD array imager for improved photon collection efficiency, spatial resolution, and portability; 2) we will harness the latest developments in Deep Learning (DL) for ultra-fast, quantitative, but fitting/iterative inverse solver-free image formation, in both 2D and 3D providing image formation/processing solutions to facilitate multiplexed imaging; 3) we will implement new functionalities in our imaging platform to enable the concurrent longitudinal imaging of multiple clinically relevant target-receptor interactions (e.g. HER receptor family members involved in many cancers) as well as metabolic and functional status across the whole-tumor region in live intact animals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$11,465 )
2025	2023	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Detection and Diagnosis Research	000	4	8/28/2025	NON-COMPETING CONTINUATION	-$11,465
														Subtotal = -$11,465

Issue Date FY: 2023 ( Subtotal = $621,773 )
2023	2023	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Detection and Diagnosis Research	000	4	4/26/2023	NON-COMPETING CONTINUATION	$621,773
														Subtotal = $621,773

Issue Date FY: 2022 ( Subtotal = $793,522 )
2022	2022	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Detection and Diagnosis Research	000	3	5/13/2022	NON-COMPETING CONTINUATION	$793,522
														Subtotal = $793,522

Issue Date FY: 2021 ( Subtotal = $824,164 )
2021	2021	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Detection and Diagnosis Research	000	2	8/24/2021	NON-COMPETING CONTINUATION	$633,791
2021	2021	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Detection and Diagnosis Research	001	2	9/20/2021	SUPPLEMENT FOR EXPANSION	$190,373
														Subtotal = $824,164

Issue Date FY: 2020 ( Subtotal = $637,634 )
2020	2020	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Cancer Detection and Diagnosis Research	000	1	4/16/2020	NEW	$637,634
														Subtotal = $637,634

Grand Total All Awards = $2,865,628

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In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging

Award Number: R01CA250636

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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