Tuesday, July 1, 2025 7/1/2025

Multicenter Quantitative MRI Assessment of Breast Cancer Therapy Response

Award Number: R01CA248192
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Multicenter Quantitative MRI Assessment of Breast Cancer Therapy Response - Project Summary Quantitative imaging of tumor biological functions have been shown superior to imaging tumor size for prediction and evaluation of cancer response to therapy. Conventionally used as a noninvasive imaging method to assess microvascular perfusion and permeability, dynamic contrast-enhanced (DCE) MRI is increasingly employed in research and early phase clinical trial settings to measure and, importantly, predict tumor response to treatment. The standard two- or three-parameter Tofts models (TMs) are the most commonly used for pharmacokinetic (PK) modeling of DCE-MRI data to estimate quantitative imaging biomarkers such as Ktrans and ve. However, the TM is suboptimal in that it ignores the real physiological phenomenon of water exchange between tissue compartments when quantifying tissue concentration of contrast agent from MRI signal intensities. The Shutter-Speed Model (SSM) developed by the Oregon Health & Science University (OHSU) group is a more comprehensive PK model, taking into account the intercompartmental water exchange kinetics. Recent single-center OHSU studies have demonstrated superior ability of SSM DCE-MRI for prediction and evaluation of therapy response in breast cancer compared to the TM. Furthermore, it was recently discovered that the SSM-exclusive parameter, τi (mean intracellular water lifetime), is a new imaging biomarker of metabolic activity, and was the only baseline (pre-treatment) marker predictive of response to neoadjuvant chemotherapy (NAC) in breast cancer and overall survival in head and neck cancer. τi also has the advantage of being significantly less sensitive to variation in arterial input function (AIF) than the conventional PK parameters. Using the data acquisition and analysis protocols optimized by the OHSU group, the overall goal of this project is to validate the robustness of SSM DCE-MRI as a quantitative imaging tool for assessment of cancer therapy response in a prospective study under a multicenter setting across three major MRI scanner platforms, using NAC treatment of breast cancer as the testing clinical application. Specifically, we will (1) implement the optimized SSM DCE-MRI data acquisition and analysis protocols and perform QA/QC in a multicenter setting; (2) conduct the multicenter prospective study to validate the utility of SSM DCE-MRI for prediction and evaluation of breast cancer response to NAC; and (3) refine an OHSU-developed web-based clinical decision support system by developing and incorporating a predictive model of therapy response that integrates imaging markers with clinical and histopathological data, and evaluate the system adaptability in clinical workflow.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	000	4	6/6/2025	NON-COMPETING CONTINUATION	-$498,399
2025	2024	WILLIAM BEAUMONT HOSPITAL	26901 BEAUMONT BLVD # 6D	SOUTHFIELD	MI	48033	OAKLAND	USA	Cancer Detection and Diagnosis Research	001	5	6/9/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$498,399
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $552,149 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	001	4	5/7/2024	NON-COMPETING CONTINUATION	$552,149
2024	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	000	3	1/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $552,149

Issue Date FY: 2023 ( Subtotal = $578,853 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	001	3	3/23/2023	NON-COMPETING CONTINUATION	$47,253
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	000	3	12/21/2022	NON-COMPETING CONTINUATION	$531,600
														Subtotal = $578,853

Issue Date FY: 2022 ( Subtotal = $585,776 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	001	2	5/6/2022	NON-COMPETING CONTINUATION	$47,818
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	000	2	11/4/2021	NON-COMPETING CONTINUATION	$537,958
														Subtotal = $585,776

Issue Date FY: 2021 ( Subtotal = $624,828 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Detection and Diagnosis Research	000	1	11/24/2020	NEW	$624,828
														Subtotal = $624,828

Grand Total All Awards = $2,341,606

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Multicenter Quantitative MRI Assessment of Breast Cancer Therapy Response

Award Number: R01CA248192

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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